Calculating the Myopic Nerve

Two-Continent Eye Study offers a risk-score approach for high myopia-associated optic neuropathies

Category	Detail
Condition	High Myopia and Associated Optic Nerve Damage
Key Mechanisms	Estimation of glaucomatous and non-glaucomatous optic neuropathy risk based on axial length, age, ethnicity, and intraocular pressure.
Target Population	Individuals aged 6 to 100 years with high myopia.
Care Setting	Ophthalmology clinics and practices.

GLON present in 2.7% of eyes; NGON in 0.3%.
Probability of GLON increases significantly with age and axial length.
Equations achieved strong performance in validation with AUC of 0.881 for GLON and 0.964 for NGON.
Diagnostic complexity noted with most GLON eyes having IOP ≤ 21 mm Hg.
Study emphasizes equations as rough estimates, not definitive predictions.

Use defined criteria for GLON and NGON based on optic nerve head abnormalities and signs of optic atrophy.

Consider factors such as age, axial length, and ethnicity when assessing optic nerve damage risk.

Individuals with high myopia, particularly those with long axial lengths.

Risk assessment can guide the need for closer structural and functional follow-up.

Utilize the developed equations to estimate optic nerve damage risk in high myopia.
Communicate risk effectively to patients to enhance understanding and compliance.
Incorporate regular assessments of axial length and IOP in management plans.