Favorable safety and immunogenicity of a combined quadrivalent influenza and recombinant SARS-CoV-2 vaccine in Sprague-Dawley rats for both primary and booster immunization - Scorecard - MDSpire

Safety and Immunogenic Response of a Novel Combined Quadrivalent Influenza and Recombinant SARS-CoV-2 Vaccine in Sprague-Dawley Rats During Primary and Booster Doses

  • By

  • Jinjin Shao

  • Chengda Zhang

  • Guangbiao She

  • Tian Qin

  • Jinyao Zhang

  • Minxi Fang

  • Dan Zhao

  • Linying Wang

  • Lijuan Xia

  • Qian Yang

  • Lili Zhang

  • Yanling Zhang

  • Siming Zhang

  • Jiahong Wang

  • Zhiqi Xie

  • Yunxiang Chen

  • Ying Chen

  • Enqi Huang

  • Lijiang Zhang

  • July 17, 2026

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Clinical Scorecard: Safety and Immunogenic Response of a Novel Combined Quadrivalent Influenza and Recombinant SARS-CoV-2 Vaccine in Sprague-Dawley Rats During Primary and Booster Doses

At a Glance

CategoryDetail
ConditionCombined Quadrivalent Influenza and Recombinant SARS-CoV-2 Vaccine
Key MechanismsInduction of IgG and neutralizing antibody responses against influenza and SARS-CoV-2.
Target PopulationSprague-Dawley rats
Care SettingPreclinical safety evaluation

Key Highlights

  • No severe or life-threatening adverse reactions observed.
  • Strong immunogenicity with effective IgG and neutralizing antibody responses.
  • Booster doses significantly enhanced antibody levels in pre-immune models.
  • Transient injection-site nodules resolved completely.
  • Study conducted in accordance with ICH S6(R1) guidelines.

Guideline-Based Recommendations

Diagnosis

    Management

      Monitoring & Follow-up

        Risks

          Patient & Prescribing Data

          Not applicable (preclinical study in rats).

          Demonstrated favorable safety profile and potent immunogenicity.

          Clinical Best Practices

          • Consider combined vaccines to reduce logistical burdens and improve coverage.
          • Monitor for transient adverse reactions at injection sites.

          Related Resources & Content

          Original Source(s)

          Favorable safety and immunogenicity of a combined quadrivalent influenza and recombinant SARS-CoV-2 vaccine in Sprague-Dawley rats for both primary and booster immunization

          • by Jinjin Shao, Chengda Zhang, Guangbiao She, Tian Qin, Jinyao Zhang, Minxi Fang, Dan Zhao, Linying Wang, Lijuan Xia, Qian Yang, Lili Zhang, Yanling Zhang, Siming Zhang, Jiahong Wang, Zhiqi Xie, Yunxiang Chen, Ying Chen, Enqi Huang, Lijiang Zhang

          • July 17, 2026

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