Feminizing hormone therapy using GnRH agonists as antiandrogens is not associated with adverse metabolic and bone effects in adult transgender women - Scorecard - MDSpire
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The Use of GnRH Agonists in Feminizing Hormone Therapy Does Not Lead to Negative Metabolic or Bone Health Outcomes in Adult Transgender Women

  • By

  • Brunet, Louise

  • Busiah, Kanetee

  • Moser, Mireille

  • Papadakis, Georgios E.

  • May 21, 2026

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Clinical Scorecard: The Use of GnRH Agonists in Feminizing Hormone Therapy Does Not Lead to Negative Metabolic or Bone Health Outcomes in Adult Transgender Women

At a Glance

CategoryDetail
Condition
Key MechanismsGnRH agonists and estrogens in gender-affirming hormone therapy focusing on metabolic and bone health outcomes
Target Population
Care Setting

Key Highlights

  • Include confidence intervals for all metrics.

Guideline-Based Recommendations

Diagnosis

  • Consider including specific diagnostic criteria for gender dysphoria.

Management

  • Outline management strategies based on metabolic and bone health outcomes.

Monitoring & Follow-up

  • Suggest monitoring frequency for metabolic and bone health.

Risks

  • Identify potential risks associated with GnRH agonists in this population.

Patient & Prescribing Data

GAHT using GnRH agonists and estrogens does not adversely affect metabolic or bone health outcomes; consider implications for prescribing.

Clinical Best Practices

  • Specify frequency and methods for assessing bone mineral density.

Related Resources & Content

Original Source(s)

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