Association of metabolic syndrome with ruptured status of intracranial aneurysms in a definitively treated cohort: a retrospective cohort analysis - Scorecard - MDSpire

Association of metabolic syndrome with ruptured status of intracranial aneurysms in a definitively treated cohort: a retrospective cohort analysis

  • By

  • Zisheng Liu

  • Xidong Wu

  • Jiaming Xu

  • Jianyong Cai

  • Huajun Ba

  • Qun Lin

  • Jun Sun

  • Weizhong Shi

  • May 22, 2026

  • 0 min

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Clinical Scorecard: Link Between Metabolic Syndrome and Ruptured Intracranial Aneurysms in a Treated Patient Cohort: A Retrospective Analysis

At a Glance

CategoryDetail
ConditionMetabolic Syndrome and Ruptured Intracranial Aneurysms
Key MechanismsSystemic inflammation and endothelial dysfunction associated with Metabolic Syndrome.
Target PopulationPatients with intracranial aneurysms undergoing definitive treatment.
Care SettingSingle-center retrospective cohort analysis.

Key Highlights

  • MetS prevalence: 59.9% in ruptured vs. 40.1% in unruptured aneurysms.
  • Binary MetS associated with ruptured status (adjusted OR 1.83).
  • Elevated glucose, reduced HDL cholesterol, and elevated blood pressure showed strongest associations.
  • Higher MetS scores correlated with increased ruptured status.
  • Study emphasizes associative findings, requiring prospective validation.

Guideline-Based Recommendations

Diagnosis

  • Assess presence of Metabolic Syndrome using standard components.

Management

  • Consider MetS as a factor in evaluating ruptured aneurysm risk.

Monitoring & Follow-up

  • Monitor individual components of MetS in patients with intracranial aneurysms.

Risks

  • Increased risk of ruptured aneurysms associated with MetS.

Patient & Prescribing Data

Patients with intracranial aneurysms treated at Wenzhou Central Hospital.

Focus on managing MetS components to potentially influence aneurysm stability.

Clinical Best Practices

  • Incorporate assessment of MetS in the management of patients with intracranial aneurysms.
  • Utilize multivariable logistic regression for evaluating ruptured status.

Related Resources & Content

Original Source(s)

Association of metabolic syndrome with ruptured status of intracranial aneurysms in a definitively treated cohort: a retrospective cohort analysis

  • by Zisheng Liu, Xidong Wu, Jiaming Xu, Jianyong Cai, Huajun Ba, Qun Lin, Jun Sun, Weizhong Shi

  • May 22, 2026

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