Infantile pulmonary abscess due to Mycobacterium abscessus subsp. massiliense identified by integrated mNGS and targeted NGS: a rare case report - Scorecard - MDSpire

Infantile pulmonary abscess due to Mycobacterium abscessus subsp. massiliense identified by integrated mNGS and targeted NGS: a rare case report

  • By

  • Huanhuan Zhu

  • Yuting Lin

  • Hailing Liao

  • Xuming Li

  • Qingke Xie

  • Yinan Zheng

  • June 12, 2026

  • 0 min

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Clinical Scorecard: Pulmonary Abscess in an Infant Caused by Mycobacterium abscessus subsp. massiliense: A Case Study Utilizing Integrated mNGS and Targeted NGS for Diagnosis

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target PopulationInfants, particularly those without underlying conditions
Care Setting

Key Highlights

  • Rare case of pulmonary infection in a 3-month-old infant
  • Initial diagnosis aided by mNGS followed by tNGS for species identification
  • Histopathological examination confirmed granulomatous inflammation

Guideline-Based Recommendations

Diagnosis

  • Utilize mNGS for initial detection of pathogens in inconclusive cases
  • Employ tNGS for precise species identification

Management

  • Initiate multidrug therapy for NTM infections based on susceptibility

Monitoring & Follow-up

  • Regular follow-up imaging and clinical assessments

Risks

  • Potential for misdiagnosis due to overlapping clinical features

Patient & Prescribing Data

Combination therapy including azithromycin, imipenem-cilastatin, cefoxitin, and linezolid

Clinical Best Practices

  • Consider NTM infections in infants presenting with persistent respiratory symptoms
  • Integrate advanced sequencing technologies for accurate diagnosis

Related Resources & Content

Original Source(s)

Infantile pulmonary abscess due to Mycobacterium abscessus subsp. massiliense identified by integrated mNGS and targeted NGS: a rare case report

  • by Huanhuan Zhu, Yuting Lin, Hailing Liao, Xuming Li, Qingke Xie, Yinan Zheng

  • June 12, 2026

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