Sensitivity and specificity of speckle tracking echocardiography for coronary artery disease: a systematic review and meta-analysis - Scorecard - MDSpire
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Diagnostic Accuracy of Speckle Tracking Echocardiography in Identifying Coronary Artery Disease: A Systematic Review and Meta-Analysis

  • By

  • Linping Xu

  • Haoqi Xu

  • Zhi Pan

  • Ruizhong Ye

  • August 28, 2026

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Clinical Scorecard: Diagnostic Accuracy of Speckle Tracking Echocardiography in Identifying Coronary Artery Disease: A Systematic Review and Meta-Analysis

At a Glance

CategoryDetail
ConditionCoronary Artery Disease (CAD)
Key MechanismsSpeckle tracking echocardiography (STE) measures myocardial strain parameters to identify CAD.
Target PopulationPatients with suspected CAD.
Care SettingDiagnostic imaging and cardiology.

Key Highlights

  • Pooled STE sensitivity for CAD was 77.3% and specificity was 75.0%.
  • Global longitudinal strain (GLS) showed sensitivity of 78.6% and specificity of 76.3%.
  • Global area strain (GAS) had the highest sensitivity at 83.3%, but moderate specificity.
  • Exercise stress STE demonstrated greater sensitivity compared to dobutamine stress or no-stress protocols.
  • Overall certainty of evidence was assessed as low due to high risk of bias and imprecision.

Guideline-Based Recommendations

Diagnosis

  • Coronary angiography (CAG) is the clinical standard for CAD diagnosis.

Management

  • Incorporate STE into multidisciplinary diagnostic pathways.

Monitoring & Follow-up

  • Prioritize methodological standardization and validation of strain thresholds.

Risks

  • CAG entails risks, radiation exposure, and healthcare costs.

Patient & Prescribing Data

Individuals with clinical suspicion of CAD.

STE provides a non-invasive alternative for early detection of myocardial dysfunction.

Clinical Best Practices

  • Utilize GLS in standard echocardiographic examinations when feasible.
  • Focus on quantitative assessment of myocardial mechanics using STE.

Related Resources & Content

Original Source(s)

Sensitivity and specificity of speckle tracking echocardiography for coronary artery disease: a systematic review and meta-analysis

  • by Linping Xu, Haoqi Xu, Zhi Pan, Ruizhong Ye

  • August 28, 2026

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