Evaluating the association between upstream perceived individual and neighborhood determinants of health and intensity of breast cancer screening - Scorecard - MDSpire

Evaluating the association between upstream perceived individual and neighborhood determinants of health and intensity of breast cancer screening

  • By

  • Faith Morley

  • Anjile An

  • Vivian Bea

  • Rulla M Tamimi

  • Kevin H Kensler

  • October 22, 2025

  • 0 min

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Clinical Scorecard: Assessing the Link Between Perceived Individual and Neighborhood Health Determinants and Mammography Screening Frequency

At a Glance

CategoryDetail
ConditionBreast cancer screening via mammography
Key MechanismsImpact of perceived individual stress and discrimination, and neighborhood factors on mammography screening rates
Target PopulationWomen aged 40-74 without history of breast cancer, including non-Hispanic Black, Hispanic, and non-Hispanic White women
Care SettingPrimary care and screening facilities within health systems participating in the All of Us Research Program

Key Highlights

  • Higher perceived stress and discrimination are associated with lower mammography screening rates.
  • Perceived neighborhood physical disorder and social cohesion were not significantly associated with screening rates.
  • Disparities in screening related to stress and discrimination do not differ by race and ethnicity, but Hispanic women have lower overall screening rates.

Guideline-Based Recommendations

Diagnosis

  • Identify women aged 40-74 for breast cancer screening eligibility.
  • Assess patient-reported stress and experiences of discrimination as part of social determinants of health screening.

Management

  • Address barriers related to high stress and discrimination to improve mammography uptake.
  • Provide culturally sensitive education and support to marginalized groups to enhance screening adherence.

Monitoring & Follow-up

  • Track mammography screening rates longitudinally, especially in populations reporting high stress and discrimination.
  • Monitor compliance with breast cancer screening guidelines across racial and ethnic groups.

Risks

  • High perceived stress and discrimination may lead to reduced screening and delayed breast cancer detection.
  • Structural and social determinants contribute to inequities in breast cancer outcomes.

Patient & Prescribing Data

31,568 female participants aged 40-74 without breast cancer history from the All of Us Research Program

52% had at least one mammogram during follow-up; higher stress and discrimination correlated with lower screening incidence rate ratios (IRR 0.84 and 0.92 respectively).

Clinical Best Practices

  • Incorporate assessment of social determinants such as stress and discrimination in routine clinical evaluations.
  • Implement targeted interventions to reduce barriers to mammography in high-stress and high-discrimination populations.
  • Recognize that neighborhood physical disorder and social cohesion may have less direct impact on screening rates compared to individual-level stress and discrimination.
  • Ensure equitable access and follow-up for repeat mammography, particularly among non-Hispanic Black and Hispanic women.

References

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