Health-related quality of life, psychological well-being and physical activity in patients with mild-to-moderate ascending aortic dilation - a cross-sectional case-control study - Scorecard - MDSpire
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Quality of Life, Mental Health, and Exercise Levels in Individuals with Mild to Moderate Ascending Aortic Dilation: A Cross-Sectional Case-Control Analysis

  • By

  • Fredrik Nilsson

  • Marcus Lindenberger

  • Sabina Borg

  • David Kylhammar

  • Petter Dyverfeldt

  • Filip Hammaréus

  • Lena Jonasson

  • Aleksandra Krzynska-Trzebiatowska

  • Lennart Nilsson

  • Chiara Trenti

  • Jan Engvall

  • Eva Swahn

  • September 21, 2026

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Clinical Scorecard: Quality of Life, Mental Health, and Exercise Levels in Individuals with Mild to Moderate Ascending Aortic Dilation: A Cross-Sectional Case-Control Analysis

At a Glance

CategoryDetail
ConditionAscending Aortic Dilation
Key MechanismsAbnormal enlargement of the aorta leading to increased risk of aortic dissection and rupture.
Target PopulationIndividuals with mild to moderate ascending aortic dilation.
Care SettingOutpatient clinic for thoracic aortic disease.

Key Highlights

  • Patients with ascending aortic dilation experience negative effects on health-related quality of life (HRQoL).
  • Psychological well-being is impacted, with potential associations between cardiovascular disease and depression.
  • Physical activity levels and restrictions may influence psychological distress in patients.

Guideline-Based Recommendations

Diagnosis

  • Ongoing surveillance for aortic dilation is required, especially when diameters reach specified thresholds.

Management

  • Prophylactic surgery may be indicated for significant aortic dilation or rapid enlargement.

Monitoring & Follow-up

  • Regular follow-up imaging to assess aortic diameter and changes over time.

Risks

  • Increased risk of aortic dissection and rupture in patients with ascending aortic dilation.

Patient & Prescribing Data

Patients diagnosed with mild to moderate ascending aortic dilation.

Limited clarity on exercise restrictions; psychological distress may increase with activity limitations.

Clinical Best Practices

  • Utilize validated HRQoL assessment tools to evaluate patient well-being.
  • Consider psychological support for patients with aortic dilation.

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