Swimming ameliorates intervertebral disc degeneration accompanied by Rpl23a downregulation and changes in its immune-inflammatory pathway - Scorecard - MDSpire

Swimming ameliorates intervertebral disc degeneration accompanied by Rpl23a downregulation and changes in its immune-inflammatory pathway

  • By

  • Yong Ji

  • Haixin Ma

  • Rong Tan

  • Xin Sha

  • Xin Li

  • June 2, 2026

  • 0 min

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Clinical Scorecard: Aquatic Exercise Mitigates Degeneration of Intervertebral Discs Through Downregulation of Rpl23a and Modifications in Immune-Inflammatory Pathways

At a Glance

CategoryDetail
Condition
Key MechanismsInvolvement of Rpl23a in immune dysregulation and NF-κB signaling pathway activation.
Target Population
Care Setting

Key Highlights

  • Rpl23a is upregulated in degenerated intervertebral discs.
  • Swimming as an exercise intervention reduces Rpl23a expression in a rat model.
  • Rpl23a overexpression leads to increased secretion of TNF-α and IL-1β.
  • Exercise improves nutrient supply to intervertebral discs.

Guideline-Based Recommendations

Diagnosis

  • Utilize RNA sequencing datasets to identify differentially expressed genes in IVDD.

Management

    Monitoring & Follow-up

    • Assess Rpl23a expression in intervertebral discs.

    Risks

      Patient & Prescribing Data

      Individuals suffering from low back pain due to IVDD.

      Clinical Best Practices

        Related Resources & Content

        Original Source(s)

        Swimming ameliorates intervertebral disc degeneration accompanied by Rpl23a downregulation and changes in its immune-inflammatory pathway

        • by Yong Ji, Haixin Ma, Rong Tan, Xin Sha, Xin Li

        • June 2, 2026

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