Human NKT10 cells are enriched in cord-derived invariant natural killer T cells and mediate immune-regulation in a xenogeneic graft-versus-host disease model - Scorecard - MDSpire

Human NKT10 cells are enriched in cord-derived invariant natural killer T cells and mediate immune-regulation in a xenogeneic graft-versus-host disease model

  • By

  • Abel Trujillo-Ocampo

  • Pamella Borges

  • Maison Grefe

  • Martiela Vaz de Freitas

  • Sung-Eun Lee

  • Yuan Qi

  • Jelita Clinton

  • Dan Li

  • Hong He

  • Ling Yu

  • Arnau Peris-Cuesta

  • Erik A. Ehli

  • Qing Ma

  • Xiaoping Su

  • Dinler Amaral Antunes

  • Gheath Al-Atrash

  • Jeffrey J. Molldrem

  • Elizabeth J. Shpall

  • Jin S. Im

  • June 10, 2026

  • 0 min

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Clinical Scorecard: Enrichment of NKT10 Cells from Cord-Derived Invariant Natural Killer T Cells and Their Role in Immune Regulation in a Xenogeneic Graft-Versus-Host Disease Model

At a Glance

CategoryDetail
Condition
Key MechanismsNKT10 cells are characterized by their production of IL-10.
Target PopulationPatients undergoing allogeneic stem cell transplantation (ASCT).
Care Setting

Key Highlights

  • Cord-derived iNKT cells contain a high frequency of CD4+CD25+CD161lowFoxP3+ iNKT cells.
  • NKT10 cells are associated with Th2/Th10-biased cytokine production.
  • Cord-derived iNKT cells suppress alloreactive T cell proliferation in vitro.

Guideline-Based Recommendations

Diagnosis

  • Characterization of iNKT cell subsets in patients undergoing ASCT.

Management

    Monitoring & Follow-up

    • Monitoring of iNKT cell levels post-transplantation.

    Risks

    • Potential for increased life-threatening infections with steroid treatment for GVHD.

    Patient & Prescribing Data

    Patients with blood cancers or disorders receiving ASCT.

    Clinical Best Practices

      Related Resources & Content

      Original Source(s)

      Human NKT10 cells are enriched in cord-derived invariant natural killer T cells and mediate immune-regulation in a xenogeneic graft-versus-host disease model

      • by Abel Trujillo-Ocampo, Pamella Borges, Maison Grefe, Martiela Vaz de Freitas, Sung-Eun Lee, Yuan Qi, Jelita Clinton, Dan Li, Hong He, Ling Yu, Arnau Peris-Cuesta, Erik A. Ehli, Qing Ma, Xiaoping Su, Dinler Amaral Antunes, Gheath Al-Atrash, Jeffrey J. Molldrem, Elizabeth J. Shpall, Jin S. Im

      • June 10, 2026

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