Vitamin D supports activated CD4+ T-cell proliferation through enhanced glutaminolysis - Scorecard - MDSpire

Vitamin D supports activated CD4+ T-cell proliferation through enhanced glutaminolysis

  • By

  • Agustín A. Vera

  • Mauricio Hernandez

  • Ricardo A. Cartes

  • Faryd Llerena

  • Solange E. Cisterna

  • Romina A. Quiroga

  • Sergio A. Sanhueza

  • Camila P. Muñoz-Grez

  • Francisco Vergara

  • Daniel Moena

  • Pablo A. Alarcón

  • Rafael Burgos

  • Coralia I. Rivas

  • Elena Uribe

  • Rafael J. Argüello

  • Cristopher Almarza

  • Felix A. Urra

  • Francisco Tapia-Belmonte

  • Luciano Ferrada

  • Liliana I. Lamperti

  • Estefanía Nova-Lamperti

  • June 11, 2026

  • 0 min

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Clinical Scorecard: Vitamin D Enhances Proliferation of Activated CD4+ T Cells via Increased Glutaminolysis

At a Glance

CategoryDetail
ConditionT cell activation and proliferation
Key MechanismsModulation of glutaminolysis and suppression of glycolysis
Target PopulationActivated CD4+ T cells
Care SettingImmunology and cellular biology research

Key Highlights

  • Vitamin D promotes CD4+ T cell proliferation via enhanced glutaminolysis.
  • VDR signaling reduces glucose uptake while maintaining T cell expansion.
  • Inhibition of glutamine metabolism impairs T cell proliferation.
  • Glutamine is essential for energy production and biosynthesis in T cells.
  • Vitamin D induces a metabolically restrained but adaptive proliferative state.

Guideline-Based Recommendations

Diagnosis

  • Evaluate T cell activation status in the context of vitamin D levels.

Management

  • Consider vitamin D supplementation in patients with T cell activation disorders.

Monitoring & Follow-up

  • Monitor glutamine levels and T cell proliferation in patients receiving vitamin D.

Risks

  • Excessive vitamin D may ultimately restrict T cell proliferation.

Patient & Prescribing Data

Individuals with immune dysregulation or deficiency in vitamin D.

Vitamin D supplementation may enhance T cell function through metabolic pathways.

Clinical Best Practices

  • Assess vitamin D status in patients with immune disorders.
  • Incorporate metabolic assessments in T cell activation studies.
  • Utilize pharmacological inhibitors to study glutamine dependence in T cells.

Related Resources & Content

Original Source(s)

Vitamin D supports activated CD4+ T-cell proliferation through enhanced glutaminolysis

  • by Agustín A. Vera, Mauricio Hernandez, Ricardo A. Cartes, Faryd Llerena, Solange E. Cisterna, Romina A. Quiroga, Sergio A. Sanhueza, Camila P. Muñoz-Grez, Francisco Vergara, Daniel Moena, Pablo A. Alarcón, Rafael Burgos, Coralia I. Rivas, Elena Uribe, Rafael J. Argüello, Cristopher Almarza, Felix A. Urra, Francisco Tapia-Belmonte, Luciano Ferrada, Liliana I. Lamperti, Estefanía Nova-Lamperti

  • June 11, 2026

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