Association of cancer-related cytokines and mitochondrial DNA alterations in hepatocellular carcinoma patients and HIV-positive individuals in Ghana - Scorecard - MDSpire
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Association of cancer-related cytokines and mitochondrial DNA alterations in hepatocellular carcinoma patients and HIV-positive individuals in Ghana
Clinical Scorecard: Association of cancer-related cytokines and mitochondrial DNA alterations in hepatocellular carcinoma patients and HIV-positive individuals in Ghana
At a Glance
Category
Detail
Condition
Hepatocellular carcinoma (HCC) in individuals living with HIV
Key Mechanisms
Cytokine secretion leading to chronic inflammation and immune dysregulation
Target Population
People living with HIV (PLWH), particularly those with HBV or HCV coinfection
Care Setting
Korle-Bu Teaching Hospital, Accra, Ghana
Key Highlights
HCC incidence is rising among PLWH, especially those aged 50 and older.
Cytokines play a significant role in the development and progression of HCC.
PLWH with HBV or HCV coinfection are at higher risk for HCC.
Chronic inflammation from cytokine imbalance is linked to cancer development.
The prevalence of HCC in HIV-endemic regions is significantly higher than in non-endemic areas.
Guideline-Based Recommendations
Diagnosis
Screening for HCC in PLWH should consider cytokine levels and liver function tests.
Management
Manage chronic hepatitis infections to reduce HCC risk in PLWH.
Monitoring & Follow-up
Regular monitoring of liver function and HIV viral load is essential.
Risks
Increased risk of HCC in PLWH with chronic HBV or HCV infections.
Patient & Prescribing Data
Adults aged 18 and above with HIV and/or HCC due to viral hepatitis.
Antiretroviral therapy (ART) reduces AIDS-defining cancers but non-AIDS-defining cancers like HCC are increasing.
Clinical Best Practices
Implement routine screening for HCC in PLWH, especially those with hepatitis coinfections.
Educate patients on the importance of regular liver function tests.
Encourage adherence to ART to manage HIV effectively.
by James Odame Aboagye, Ruth Ayanful-Torgby, Lei Zhou, Prince Peter Wormenor, Vincent Ganu, Kenneth Tachi, Bernard Nii Akrashie Attoh, Miriam Mensah, Timothy Kuuguu, Sedzro Kojo Mensah, George Boateng Kyei, Elijah Paintsil
