Macrophage Spatiotemporal Plasticity in Pulmonary Diseases: Decoding the Niche at Single-Cell Resolution
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By
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Lin, Chenchen
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Huang, Shaohui
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Yang, Li
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Wang, Ziqi
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Zhou, Huanhuan
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Zhang, Quncheng
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Zhang, Xiaoju
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June 2, 2026
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Clinical Scorecard: Exploring the Dynamic Plasticity of Macrophages in Lung Diseases: Insights from Single-Cell Analysis
At a Glance
| Category | Detail |
|---|
| Condition | |
| Key Mechanisms | Dynamic coordination of resident and recruited macrophage populations; plasticity of macrophage states. |
| Target Population | |
| Care Setting | |
Key Highlights
- Macrophage functions are not adequately captured by the M1/M2 dichotomy.
- Single-cell RNA sequencing has refined understanding of macrophage heterogeneity.
- Persistent tissue injury remodels resident macrophage programs.
- Macrophage states are linked to inflammatory amplification and tissue remodeling.
Guideline-Based Recommendations
Diagnosis
- Utilize single-cell analysis to assess macrophage states in lung diseases.
Management
- Explore macrophage-targeted strategies beyond broad depletion.
Monitoring & Follow-up
- Consider macrophage subset dynamics in monitoring disease progression.
Risks
- Monitor for inflammatory amplification and tissue remodeling associated with macrophage states.
Patient & Prescribing Data
Explore antibody-based, nanocarrier-mediated, and engineered-cell approaches for macrophage modulation.
Clinical Best Practices
- Incorporate spatial multi-omics in research to understand macrophage interactions.
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