Association of blood urea nitrogen to albumin ratio with cerebral small vessel disease and its ischemic imaging markers: a cross-sectional study - Scorecard - MDSpire
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Association of blood urea nitrogen to albumin ratio with cerebral small vessel disease and its ischemic imaging markers: a cross-sectional study
Clinical Scorecard: Relationship Between Blood Urea Nitrogen to Albumin Ratio and Cerebral Small Vessel Disease Alongside Ischemic Imaging Indicators: A Cross-Sectional Analysis
At a Glance
Category
Detail
Condition
Cerebral Small Vessel Disease (CSVD)
Key Mechanisms
Association of blood urea nitrogen to albumin ratio (BAR) with ischemic neuroimaging markers.
Target Population
Adults aged 30 to 85 years, including patients with and without CSVD.
Care Setting
Neurology Department, The First Hospital of Quanzhou Affiliated to Fujian Medical University.
Key Highlights
BAR positively associated with CSVD and ischemic markers (WMH, EPVS).
No significant association found between BAR and lacunes.
Higher BAR quantiles correlate with increased risk of CSVD.
BAR serves as a potential novel biomarker for CSVD.
Sensitivity analyses confirm robustness of associations across kidney function levels.
Guideline-Based Recommendations
Diagnosis
Utilize neuroimaging for CSVD diagnosis.
Consider BAR as a complementary biomarker for early identification.
Management
Further investigation into BAR's role in risk stratification for CSVD.
Monitoring & Follow-up
Monitor BAR levels alongside kidney function and systemic inflammation markers.
Risks
Increased risk of CSVD with higher BAR levels.
Patient & Prescribing Data
762 participants, including 452 with CSVD and 310 controls.
BAR may guide treatment strategies and monitoring in CSVD patients.
Clinical Best Practices
Incorporate BAR assessment in routine evaluations for patients at risk of CSVD.
Use BAR in conjunction with traditional neuroimaging techniques.
