The role of physical activity in an obesogenic environment for cardiovascular risk reduction across the lifespan: A Scientific Statement of the European Association of Preventive Cardiology of the ESC - Scorecard - MDSpire

The role of physical activity in an obesogenic environment for cardiovascular risk reduction across the lifespan: A Scientific Statement of the European Association of Preventive Cardiology of the ESC

  • By

  • Monika Siegrist

  • Esmée A Bakker

  • Erik J Timmermans

  • Thao Minh Lam

  • Trine Moholdt

  • Maja-Lisa Løchen

  • Henner Hanssen

  • Mayank Dalakoti

  • Jeroen Lakerveld

  • Ilonca Vaartjes

  • Pedro Marques-Vidal

  • Martin Bahls

  • January 13, 2026

  • 0 min

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Clinical Scorecard: The Impact of Physical Activity on Cardiovascular Risk Mitigation in an Obesogenic Environment Throughout Life: A Scientific Statement from the European Association of Preventive Cardiology of the ESC

At a Glance

CategoryDetail
ConditionObesity as a major risk factor for cardiovascular diseases (CVD)
Key MechanismsExcess adiposity causing inflammation, insulin resistance, dyslipidaemia, hypertension, and endothelial dysfunction leading to CVD
Target PopulationChildren and adolescents (<18 years), adults (18–64 years), and older adults (≥65 years)
Care SettingPublic health, preventive cardiology, clinical and policy settings

Key Highlights

  • Obesity prevalence is rising globally, significantly increasing CVD risk by up to 50%.
  • Physical activity (PA) reduces CVD risk independently of obesity and is a key non-pharmacological intervention.
  • The built and obesogenic environment influences PA behavior and obesity, affecting implementation of PA guidelines across the lifespan.

Guideline-Based Recommendations

Diagnosis

  • Use BMI along with anthropometric measures (waist circumference, waist-to-hip ratio, waist-to-height ratio) or body fat assessment for obesity diagnosis.
  • Consider clinical obesity diagnosis based on obesity-related organ dysfunction or physical limitations, not solely BMI.
  • Recognize preclinical obesity with metabolic abnormalities such as hyperglycaemia combined with dyslipidaemia.

Management

  • Promote physical activity as a primary strategy to mitigate cardiovascular risk in obesity.
  • Reserve pharmacological and surgical treatments for selected cases with clinical obesity and organ dysfunction.
  • Implement policies to regulate commercial influences and create supportive environments for healthy behaviors.

Monitoring & Follow-up

  • Monitor metabolic parameters including inflammation markers, insulin resistance, lipid profiles, and blood pressure.
  • Assess physical activity levels and sedentary behavior across different age groups.
  • Evaluate environmental factors influencing physical activity adherence and obesity risk.

Risks

  • Obesity-related systemic inflammation and metabolic disturbances accelerate CVD progression.
  • Sedentary behavior and obesogenic environments undermine PA effectiveness.
  • Commercial interests and food industry lobbying may hinder population-level prevention efforts.

Patient & Prescribing Data

Individuals with obesity across all age groups, including those with preclinical and clinical obesity

Physical activity should be emphasized as a foundational intervention; pharmacological and surgical options are reserved for selected clinical obesity cases with organ dysfunction.

Clinical Best Practices

  • Incorporate comprehensive obesity assessment beyond BMI, including anthropometric and metabolic criteria.
  • Advocate for increased physical activity tailored to age-specific needs and environmental contexts.
  • Address obesogenic environmental factors through multidisciplinary collaboration involving healthcare professionals and policymakers.
  • Focus on prevention strategies that integrate lifestyle modification with supportive built environments.
  • Recognize and mitigate commercial and structural determinants that promote unhealthy dietary and activity behaviors.

References

Original Source(s)

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