Misdiagnosis analysis and multidisciplinary collaborative treatment of primary cutaneous diffuse large B-cell lymphoma: case report - Scorecard - MDSpire

Misdiagnosis analysis and multidisciplinary collaborative treatment of primary cutaneous diffuse large B-cell lymphoma: case report

  • By

  • Hongjuan Ji

  • Qiao Zhang

  • Gaowei Zhang

  • Hongli Ji

  • Lei Zhao

  • June 26, 2026

  • 0 min

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Clinical Scorecard: Analysis of Misdiagnosis and Collaborative Multidisciplinary Management in Primary Cutaneous Diffuse Large B-Cell Lymphoma: A Case Study

At a Glance

CategoryDetail
ConditionPrimary Cutaneous Diffuse Large B-Cell Lymphoma (PC-DLBCL)
Key MechanismsNonspecific cutaneous manifestations leading to misdiagnosis and rapid progression.
Target PopulationElderly patients, particularly those with advanced ulcerative lesions.
Care SettingMultidisciplinary collaboration in a hospital setting.

Key Highlights

  • PC-DLBCL is often misdiagnosed due to nonspecific symptoms.
  • Early pathological biopsy is crucial for accurate diagnosis.
  • Multidisciplinary management improved clinical outcomes.
  • Patient underwent orthopedic debridement and R-miniCHOP immunochemotherapy.
  • Complete resolution of skin lesions was achieved without recurrence.

Guideline-Based Recommendations

Diagnosis

  • Pathological biopsy is essential for confirming PC-DLBCL.

Management

  • Multidisciplinary collaboration between orthopedics and hematology-oncology is recommended.

Monitoring & Follow-up

  • Regular follow-up to assess for recurrence and recovery.

Risks

  • Delayed treatment can lead to severe ulceration and secondary infections.

Patient & Prescribing Data

Elderly patients with misdiagnosed skin lesions.

Combination of surgical and chemotherapeutic interventions yielded favorable outcomes.

Clinical Best Practices

  • Implement early pathological evaluation for skin lesions.
  • Encourage multidisciplinary team discussions for complex cases.
  • Monitor elderly patients closely for signs of misdiagnosis.

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