Intestinal metastases diffused from primary gastric adenocarcinoma with signet ring cells: case report
-
By
-
Haiping Qi
-
Weiyan Li
-
Xingting Luo
-
Bin Huang
-
Xiaoguang Shi
-
Xuhua Xiao
-
July 13, 2026
Clinical Scorecard: Case Study of Intestinal Metastases Arising from Primary Gastric Adenocarcinoma with Signet Ring Cell Characteristics
At a Glance
| Category | Detail |
|---|
| Condition | Gastric Adenocarcinoma with Signet Ring Cell Characteristics |
| Key Mechanisms | High metastatic capacity with uncommon intestinal metastases, primarily through lymphatic spread. |
| Target Population | Patients with gastric adenocarcinoma, particularly those exhibiting signet ring cell features. |
| Care Setting | Oncology and gastroenterology clinical settings. |
Key Highlights
- Signet ring cell carcinoma (SRCC) is a poorly differentiated subtype of gastric adenocarcinoma.
- Intestinal metastases from gastric SRCC are rare and can present as polypoid lesions.
- Elevated serum CEA levels may indicate advanced disease.
- Differentiation between metastatic gastric SRCC and primary colorectal carcinoma can be aided by CK7 and CK20 expression.
- Systemic chemotherapy is typically favored over surgical intervention for widespread lesions.
Guideline-Based Recommendations
Diagnosis
- Histopathological examination of biopsy specimens is essential for diagnosis.
Management
- Systemic chemotherapy is preferred for treatment of widespread lesions.
Monitoring & Follow-up
- Regular monitoring of serum tumor markers such as CEA.
Risks
- High risk of severe complications from chemotherapy, including bone marrow suppression.
Patient & Prescribing Data
62-year-old male with primary gastric SRCC and multiple intestinal metastases.
Patient underwent one cycle of chemotherapy with tislelizumab and oxaliplatin but declined further treatment due to complications.
Clinical Best Practices
- Conduct thorough endoscopic evaluations to identify metastatic lesions.
- Utilize immunohistochemical staining for accurate diagnosis of SRCC.
- Consider patient financial concerns when recommending genetic testing.
Related Resources & Content
