Migraine phenotypes defined by disability, pain topography and autonomic features: association with serum vitamin D status - Scorecard - MDSpire

Migraine phenotypes defined by disability, pain topography and autonomic features: association with serum vitamin D status

  • By

  • Majed Mohammad Alabdali

  • July 8, 2026

  • 0 min

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Clinical Scorecard: Characterization of Migraine Subtypes Based on Disability, Pain Distribution, and Autonomic Characteristics: Correlation with Serum Vitamin D Levels

At a Glance

CategoryDetail
ConditionMigraine
Key MechanismsClinical heterogeneity, vitamin D levels, autonomic symptoms
Target PopulationMigraine patients attending a neurology outpatient clinic
Care SettingNeurology outpatient clinic

Key Highlights

  • Four distinct migraine phenotypes identified through cluster analysis
  • Vitamin D deficiency prevalent among migraine patients (mean 17.01 ng/mL)
  • Female sex significantly predicts severe phenotype membership
  • No significant difference in vitamin D levels across migraine phenotypes

Guideline-Based Recommendations

Diagnosis

  • Utilize cluster analysis to identify migraine phenotypes based on clinical features

Management

  • Consider vitamin D levels in the context of migraine management

Monitoring & Follow-up

  • Monitor serum vitamin D levels in migraine patients

Risks

  • High prevalence of vitamin D deficiency in migraine patients

Patient & Prescribing Data

Migraine patients with varying degrees of disability and symptoms

Clinical Best Practices

  • Incorporate routine assessment of clinical features to stratify migraine patients
  • Recognize the role of female sex in predicting severe migraine phenotypes

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