Study of Aging Pioneered at Cedars-Sinai
Age is the largest risk factor for chronic disease, but medicine has yet to develop effective defenses against the most destructive elements of aging.
Clinical Scorecard: Study of Aging Pioneered at Cedars-Sinai
At a Glance
Category Detail
Condition Aging and age-related diseases Key Mechanisms Inflammation, immunity shifts, epigenetics, stem cell dysfunction, metabolic dysfunction, proteostasis, cellular senescence Target Population Older adults, particularly those with chronic diseases Care Setting Clinical trials and translational research centers
Key Highlights
Age is the largest risk factor for chronic diseases, including dementia and Alzheimer's. Cedars-Sinai is conducting pioneering clinical trials on the molecular impacts of aging. Research focuses on interconnected mechanisms of aging to develop targeted interventions. The population of older adults in the U.S. is expected to double in the next 25 years. Geroscience aims to streamline screening and treatment for aging-related conditions. Guideline-Based Recommendations
Diagnosis
Utilize biomarkers for early detection of age-related cognitive decline and dementia. Management
Implement lifestyle interventions and medications targeting aging mechanisms. Monitoring & Follow-up
Conduct longitudinal studies to assess the impact of interventions on aging. Risks
Advanced age is associated with multiple chronic diseases and complex health challenges. Patient & Prescribing Data
Older adults, particularly those with multiple chronic conditions
Clinical trials are exploring the effects of exercise, diet, and medications on aging.
Clinical Best Practices
Focus on understanding the broader pathophysiological mechanisms of aging. Collaborate across specialties to address multifactorial geriatric syndromes. Ensure rigorous clinical trials to validate interventions for aging. References
