Clinical Scorecard: Clinical Features and Determinants of In-Hospital Mortality in Patients with Stenotrophomonas maltophilia Infections: A Retrospective Cohort Analysis from a Single Center

At a Glance

Key Highlights

• In-hospital mortality rate was 11.8% among the cohort.
• Older age and higher Charlson Comorbidity Index (CCI) values were associated with increased mortality.
• Mechanical ventilation was strongly associated with mortality but did not reach statistical significance.
• Previous carbapenem exposure did not differ in mortality outcomes.
• High in vitro activity was noted for minocycline, cefoperazone/sulbactam, doxycycline, and tigecycline.

Guideline-Based Recommendations

Diagnosis

• Confirm S. maltophilia infection through clinical and microbiological evaluation.

Management

• Prioritize early risk stratification and thorough evaluation of comorbidity burden.

Monitoring & Follow-up

• Monitor for signs of septic shock and organ failure.

Risks

• Increased mortality linked to advanced age, comorbidity burden, and mechanical ventilation.

Patient & Prescribing Data

458 inpatients with confirmed S. maltophilia infection.

Empirical therapy should be informed by local susceptibility patterns.

Clinical Best Practices

• Initiate prompt supportive care for critically ill patients.
• Evaluate appropriateness of empirical antimicrobial therapy based on susceptibility testing.

Related Resources & Content

• Clinical Features and Determinants of In-Hospital Mortality in Patients with Stenotrophomonas maltophilia Infections