Insulinoma in pregnancy: a case report and literature review of diagnostic challenges, multidisciplinary management, and therapeutic dilemmas
Clinical Scorecard: Insulinoma in Expectant Mothers: A Case Study and Review of Diagnostic Challenges, Collaborative Care, and Treatment Issues
At a Glance
Category Detail
Condition Key Mechanisms Endogenous hyperinsulinaemia leading to recurrent hypoglycaemia due to insulinoma. Target Population Care Setting
Key Highlights
Insulinoma is exceedingly rare in pregnancy, with fewer than 30 cases reported. Diagnosis is often delayed due to overlapping symptoms with normal pregnancy. A multidisciplinary team approach is crucial for management. Medical therapy with octreotide can achieve partial glycaemic control, but may have teratogenic risks. Endoscopic ultrasound-guided radiofrequency ablation may require multiple sessions for glycaemic stabilization. Guideline-Based Recommendations
Diagnosis
Consider biochemical evaluation for endogenous hyperinsulinaemia in cases of recurrent hypoglycaemia. Management
Balance risks of maternal hypoglycaemia against potential fetal harm when choosing treatment strategies. Monitoring & Follow-up
Regular monitoring of maternal and fetal health is essential due to risks associated with insulinoma. Risks
Potential risks include miscarriage, preterm labor, and maternal morbidity from surgical interventions. Patient & Prescribing Data
Medical therapies such as diazoxide and somatostatin analogues may have teratogenic risks; specific risks should be discussed with patients.
Clinical Best Practices
Utilize a multidisciplinary team for individualized management of insulinoma in pregnancy. Employ imaging modalities like MRI for better detection of pancreatic lesions. Educate patients on recognizing symptoms of hypoglycaemia. Related Resources & Content
