Autonomous Oxygen Titration for Maintaining Normoxemia in Acutely Ill Adults: The SAVE-O 2 AI Randomized - Scorecard - MDSpire
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Automated Oxygen Adjustment for Sustaining Normoxemia in Critically Ill Adults: Results from the SAVE-O 2 AI Trial

  • By

  • David J. Douin

  • John D. Rice

  • Mengli Xiao

  • Laurel E. Beaty

  • Claire J. Guo

  • Cori Withers

  • Amy Sullivan

  • Erin L. Anderson

  • Alex C. Cheng

  • Mary K. Banasiewicz

  • Matthew W. Semler

  • Bradley D. Lloyd

  • Amelia W. Maiga

  • Kevin W. Gibbs

  • Gregory R. Stettler

  • Akram Khan

  • Mitchell B. Sally

  • Franklin L. Wright

  • Arek J. Wiktor

  • Neil R. Aggarwal

  • Vikhyat S. Bebarta

  • Adit A. Ginde

  • SAVE-O AI Investigators

  • Laura G. Murphy

  • Erika V. Alor

  • Yvette R. Evans

  • Laura A. Aguilar-Marquez

  • Jessica Cwik

  • Katie Gray

  • Dagmawit Getachew

  • April Johnson

  • Jakea D. Johnson

  • Karen F. Miller

  • Tracy L. Morgan

  • Shannon K. Pugh

  • Edward T. Qian

  • Colleen Ratcliff

  • Sabrina A. Shipman

  • Adam Turner

  • Lakeysha C. Wiggins

  • Genesis Briceno

  • Aidan Flieger

  • Nola Iwasaki

  • Riya Mathew

  • Chloe K. Ouchida

  • Jose Pena

  • Edvinas Pocius

  • Emily Tribbet

  • Samantha Underwood

  • Heather L. Clark

  • Copeland Graham

  • Leigha Landreth

  • Lisa Parks

  • Darija Ward

  • October 1, 2026

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Clinical Scorecard: Automated Oxygen Adjustment for Sustaining Normoxemia in Critically Ill Adults: Results from the SAVE-O 2 AI Trial

At a Glance

CategoryDetail
ConditionHypoxemia in critically ill adults
Key MechanismsAutonomous oxygen titration to maintain oxygen saturation within a specified target range
Target PopulationHospitalized adults aged 18 years or older with acute respiratory illness, trauma, burns, or acute care surgery
Care SettingTertiary care hospitals

Key Highlights

  • Autonomous oxygen titration may increase time in normoxemia compared to usual care
  • Trial involved 4 tertiary care hospitals across distinct US regions
  • Participants wore two pulse oximeters for monitoring
  • Target Spo2 was set at 93% with an acceptable range of 90%-96%
  • Study received FDA investigational device exemption

Guideline-Based Recommendations

Diagnosis

  • Monitor peripheral oxygen saturation (Spo2) using pulse oximetry

Management

  • Utilize autonomous oxygen titration systems for maintaining Spo2 within target range

Monitoring & Follow-up

  • Regular assessment of Spo2 and oxygen flow rate in accordance with clinical protocols

Risks

  • Potential exposure to hypoxemia between assessments in usual care

Patient & Prescribing Data

Hospitalized adults receiving supplemental oxygen

Autonomous titration may provide a more consistent approach to managing oxygen levels

Clinical Best Practices

  • Ensure regular monitoring of Spo2 levels
  • Educate clinical staff on recommended Spo2 targets and acceptable ranges
  • Utilize closed-loop systems where available for oxygen titration

Related Resources & Content

Original Source(s)

Autonomous Oxygen Titration for Maintaining Normoxemia in Acutely Ill Adults: The SAVE-O 2 AI Randomized

  • by David J. Douin, John D. Rice, Mengli Xiao, Laurel E. Beaty, Claire J. Guo, Cori Withers, Amy Sullivan, Erin L. Anderson, Alex C. Cheng, Mary K. Banasiewicz, Matthew W. Semler, Bradley D. Lloyd, Amelia W. Maiga, Kevin W. Gibbs, Gregory R. Stettler, Akram Khan, Mitchell B. Sally, Franklin L. Wright, Arek J. Wiktor, Neil R. Aggarwal, Vikhyat S. Bebarta, Adit A. Ginde, SAVE-O AI Investigators, Laura G. Murphy, Erika V. Alor, Yvette R. Evans, Laura A. Aguilar-Marquez, Jessica Cwik, Katie Gray, Dagmawit Getachew, April Johnson, Jakea D. Johnson, Karen F. Miller, Tracy L. Morgan, Shannon K. Pugh, Edward T. Qian, Colleen Ratcliff, Sabrina A. Shipman, Adam Turner, Lakeysha C. Wiggins, Genesis Briceno, Aidan Flieger, Nola Iwasaki, Riya Mathew, Chloe K. Ouchida, Jose Pena, Edvinas Pocius, Emily Tribbet, Samantha Underwood, Heather L. Clark, Copeland Graham, Leigha Landreth, Lisa Parks, Darija Ward

  • October 1, 2026

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