Surgery-based treatment and prognostic factors in patients with limited-stage small cell lung cancer: a retrospective cohort study - Scorecard - MDSpire

Surgery-based treatment and prognostic factors in patients with limited-stage small cell lung cancer: a retrospective cohort study

  • By

  • Mingbo Wang

  • Heng Zhao

  • Yuefeng Zhang

  • Huilai Lv

  • Qin Chu

  • Yonggang Zhu

  • Chunyue Gai

  • Ziqiang Tian

  • May 13, 2026

  • 0 min

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Clinical Scorecard: Assessment of Surgical Interventions and Prognostic Indicators in Patients with Limited-Stage Small Cell Lung Cancer: A Retrospective Analysis

At a Glance

CategoryDetail
ConditionLimited-Stage Small Cell Lung Cancer (LS-SCLC)
Key MechanismsSurgery combined with adjuvant chemotherapy and thoracic radiotherapy improves survival outcomes.
Target PopulationPatients with histopathologically confirmed LS-SCLC who underwent complete R0 resection.
Care SettingThoracic Surgery Department, Fourth Hospital of Hebei Medical University.

Key Highlights

  • Median overall survival (OS) of 81 months; 5-year OS rate of 58.3%.
  • Patients with stage I-IIA had significantly better survival than those with stage IIB-IIIB.
  • Postoperative brain metastasis significantly worsens outcomes.
  • Adjuvant chemotherapy plus thoracic radiotherapy is associated with improved survival.
  • Advanced pTNM stage identified as an independent adverse prognostic factor.

Guideline-Based Recommendations

Diagnosis

  • Histopathological confirmation of SCLC is essential.

Management

  • Surgical resection should be considered in selected patients with LS-SCLC.

Monitoring & Follow-up

  • Regular follow-up and imaging to detect postoperative progression.

Risks

  • Postoperative brain metastasis is associated with poor outcomes.

Patient & Prescribing Data

103 patients with LS-SCLC who underwent complete R0 resection.

Combination of surgery with adjuvant chemotherapy and thoracic radiotherapy improves survival, particularly in early-stage disease.

Clinical Best Practices

  • Incorporate surgical resection within a multidisciplinary treatment framework.
  • Tailor adjuvant treatment based on pathological staging.

Related Resources & Content

Original Source(s)

Surgery-based treatment and prognostic factors in patients with limited-stage small cell lung cancer: a retrospective cohort study

  • by Mingbo Wang, Heng Zhao, Yuefeng Zhang, Huilai Lv, Qin Chu, Yonggang Zhu, Chunyue Gai, Ziqiang Tian

  • May 13, 2026

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