Acute acalculous cholecystitis in children due to EBV and cytomegalovirus infection: a rare case report and review of the literature - Scorecard - MDSpire

Acute acalculous cholecystitis in children due to EBV and cytomegalovirus infection: a rare case report and review of the literature

  • By

  • Wenling Ding

  • Renchang Liu

  • June 22, 2026

  • 0 min

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Clinical Scorecard: A Rare Case of Acute Acalculous Cholecystitis in Pediatric Patients Associated with EBV and CMV Infections: A Comprehensive Literature Review

At a Glance

CategoryDetail
ConditionAcute Acalculous Cholecystitis (AAC)
Key MechanismsEBV and CMV coinfection leading to infectious mononucleosis and subsequent AAC.
Target PopulationPediatric patients, particularly those with infectious mononucleosis.
Care SettingPediatric emergency department

Key Highlights

  • AAC is rare in children and often misdiagnosed.
  • EBV and CMV coinfection can complicate infectious mononucleosis.
  • Conservative management can be effective in AAC without surgical intervention.
  • Recognition of viral AAC is crucial to avoid unnecessary antibiotic use.

Guideline-Based Recommendations

Diagnosis

  • Consider EBV/CMV coinfection in children presenting with fever and abdominal pain.

Management

  • Conservative treatment includes fasting, intravenous fluids, antispasmodics, analgesics, and antiviral therapy.

Monitoring & Follow-up

  • Monitor clinical and radiological improvement to guide management decisions.

Risks

  • Misdiagnosis of AAC as bacterial infection may lead to unnecessary antibiotic treatment and surgical intervention.

Patient & Prescribing Data

Children with infectious mononucleosis and suspected AAC.

Acyclovir may be beneficial in managing viral infections associated with AAC.

Clinical Best Practices

  • Perform thorough clinical evaluation including imaging for suspected AAC.
  • Discontinue antibiotics if AAC is determined to be viral in origin.
  • Educate families on the importance of follow-up after resolution of acute symptoms.

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