Short-term cardiotoxicity and early echocardiographic changes following autologous hematopoietic stem cell transplantation: a single-center retrospective analysis - Scorecard - MDSpire
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Short-term cardiotoxicity and early echocardiographic changes following autologous hematopoietic stem cell transplantation: a single-center retrospective analysis
Clinical Scorecard: Acute Cardiotoxic Effects and Initial Echocardiographic Alterations After Autologous Hematopoietic Stem Cell Transplantation: A Retrospective Study from a Single Institution
At a Glance
Category
Detail
Condition
Key Mechanisms
Echocardiographic changes in left ventricular ejection fraction (LVEF) and valvular disease incidence should be directly attributed to study findings.
Target Population
Care Setting
Key Highlights
Statistically significant decline in mean LVEF post-ASCT (p = 0.016)
Increase in prevalence of valvular abnormalities from 42% to 50.7% post-ASCT (p = 0.073)
Pre-existing LV dysfunction significantly associated with post-transplant LV dysfunction and valvular disease
Male gender linked to higher incidence of valvular disease (p = 0.024)
Guideline-Based Recommendations
Diagnosis
Echocardiographic evaluation pre- and post-ASCT to assess cardiac function
Management
Monitor for declines in LVEF and new valvular disease post-ASCT
Monitoring & Follow-up
Systematic echocardiographic reassessment at day +100 post-transplant
Risks
Increased risk of cardiomyopathy, heart failure, arrhythmias, and valvular disease post-ASCT
Patient & Prescribing Data
205 patients with lymphoma and Multiple Myeloma
High-dose chemotherapy followed by ASCT; conditioning regimens include BEAM and high-dose melphalan
by Jean El Cheikh, Maria El Tannir, Ali Awada, Ali Tarhini, Nour Moukalled, Iman Abou Dalle, Omar Fakhreddine, Walid Gharzuddin, Ali Bazarbachi, Hadi Skouri
