Experimental evidence of electroacupuncture in ALS mouse models: a systematic review and meta-analysis
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By
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Mengwan Hu
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Lei You
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Xuezhuo Zhang
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Zhibo Xuan
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Sijia Ma
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Xian Wu
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July 1, 2026
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Clinical Scorecard: Systematic Review and Meta-Analysis of Electroacupuncture's Effects in Mouse Models of Amyotrophic Lateral Sclerosis
At a Glance
| Category | Detail |
|---|
| Condition | Amyotrophic Lateral Sclerosis (ALS) |
| Key Mechanisms | Neuroinflammation modulation, neuronal survival promotion, axonal regeneration improvement, RNA metabolism stabilization. |
| Target Population | Mouse models of ALS. |
| Care Setting | Preclinical research. |
Key Highlights
- Electroacupuncture (EA) significantly improved motor function in ALS mice (SMD = 3.31, p < 0.001).
- EA alleviated neuroinflammation and promoted neuronal survival.
- EA slowed disease progression and prolonged survival time.
Guideline-Based Recommendations
Diagnosis
Management
Monitoring & Follow-up
Risks
Patient & Prescribing Data
Not applicable; study conducted on mouse models.
EA shows promise in modulating key pathological processes in ALS.
Clinical Best Practices
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