Distinct mucosa-associated microbiota signatures and dysbiosis in Peutz-Jeghers syndrome polyps versus paired normal mucosa
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By
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Shuai Tang
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Lei Wang
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Chong-xi Fan
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Zhe-yi Han
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Lei Zhang
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Bai-rong Li
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Shou-Bin Ning
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June 22, 2026
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Clinical Scorecard: Unique Microbiota Profiles and Dysbiosis in Polyps of Peutz-Jeghers Syndrome Compared to Corresponding Normal Mucosa
At a Glance
| Category | Detail |
|---|
| Condition | Peutz-Jeghers Syndrome (PJS) |
| Key Mechanisms | Mucosal microbial dysbiosis associated with gastrointestinal hamartomatous polyps. |
| Target Population | Patients with genetically confirmed Peutz-Jeghers syndrome. |
| Care Setting | Gastroenterology department, Air Force Medical Center. |
Key Highlights
- Significant reduction in alpha diversity in PJS polyps compared to normal mucosa.
- Polyps enriched in Pseudomonadota and depleted in Bacillota and Bacteroidota.
- Higher microbial dysbiosis index in polyps.
- Random forest model achieved AUC = 0.897 for polyp classification.
- Correlations identified between specific microbes and clinical parameters.
Guideline-Based Recommendations
Diagnosis
- Diagnosis based on histologically confirmed hamartomatous polyps or family history.
Management
- Standardized bowel preparation prior to procedures.
Monitoring & Follow-up
- Regular surveillance for polyp development and associated malignancies.
Risks
- Increased risk of multiple malignancies associated with PJS.
Patient & Prescribing Data
Patients aged 14–80 years with stable vital signs and BMI < 30 kg/m².
Exclusion of patients with significant comorbidities or recent use of certain medications.
Clinical Best Practices
- Utilize paired-sample design for microbiota studies to minimize variability.
- Employ advanced bioinformatics for microbial profiling.
- Consider microbial dysbiosis as a potential therapeutic target.
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