Single-point insulin sensitivity estimator and left main and/or three-vessel disease in patients aged 45 years or older with acute coronary syndrome: findings from the CCC-ACS project - Scorecard - MDSpire

Single-point insulin sensitivity estimator and left main and/or three-vessel disease in patients aged 45 years or older with acute coronary syndrome: findings from the CCC-ACS project

  • By

  • Mengchen Li

  • Yuyang Sun

  • Yu Liu

  • Yan Sun

  • Dai Zhang

  • Yujing Cheng

  • Xiaoli Liu

  • July 9, 2026

  • 0 min

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Clinical Scorecard: Association of Single-Point Insulin Sensitivity Estimator with Severe Coronary Disease in Patients Aged 45 and Older Experiencing Acute Coronary Syndrome: Insights from the CCC-ACS Study

At a Glance

CategoryDetail
ConditionAcute Coronary Syndrome (ACS)
Key MechanismsAssociation of insulin sensitivity with severe coronary anatomical patterns.
Target PopulationPatients aged 45 and older experiencing ACS.
Care SettingNational registry and quality improvement initiative for ACS care.

Key Highlights

  • Higher SPISE associated with lower odds of severe coronary anatomical outcomes.
  • Each 1-unit increase in SPISE linked to lower odds of left main and/or three-vessel disease.
  • Inverse associations mainly observed in patients aged <65 years.
  • Subgroup analyses showed age-related heterogeneity.
  • SPISE may serve as a marker for identifying high-risk coronary anatomy.

Guideline-Based Recommendations

Diagnosis

  • Use SPISE as a surrogate marker for insulin sensitivity in ACS patients.

Management

  • Consider metabolic markers in evaluating coronary anatomical disease.

Monitoring & Follow-up

  • Monitor SPISE levels in relation to coronary disease severity.

Risks

  • Higher insulin resistance may correlate with worse coronary outcomes.

Patient & Prescribing Data

Middle-aged and older patients with ACS.

SPISE may help identify patients at higher risk for severe coronary disease.

Clinical Best Practices

  • Incorporate SPISE in routine assessments of patients with ACS.
  • Utilize subgroup analyses to tailor treatment strategies based on age.

Related Resources & Content

Original Source(s)

Single-point insulin sensitivity estimator and left main and/or three-vessel disease in patients aged 45 years or older with acute coronary syndrome: findings from the CCC-ACS project

  • by Mengchen Li, Yuyang Sun, Yu Liu, Yan Sun, Dai Zhang, Yujing Cheng, Xiaoli Liu

  • July 9, 2026

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