Progression of mitral and tricuspid regurgitation in patients with and without atrial fibrillation
By
Michael Koechlin
Rebecca E. Paladini
Stefanie Aeschbacher
Christine S. Zuern
Ivo Strebel
Michael Coslovsky
Matea Liskij
Ruben Kerler
Philipp Krisai
Leo H. Bonati
David Conen
Felix Mahfoud
Stefan Osswald
Michael Kühne
Beat A. Kaufmann
July 1, 2026
Clinical Scorecard: Evaluation of Mitral and Tricuspid Regurgitation Progression in Patients with Atrial Fibrillation Compared to Those without
At a Glance
Category Detail
Condition Mitral and Tricuspid Regurgitation Key Mechanisms Atrial fibrillation contributes to structural remodeling of the atria and annulus, leading to regurgitation. Target Population Patients with and without atrial fibrillation aged 65 and older. Care Setting Multicenter cohort studies in Switzerland.
Key Highlights
AF is associated with higher rates of tricuspid regurgitation progression. Incidence rates of MR progression were lower in AF patients compared to non-AF patients. AF was not associated with progression of mitral regurgitation. Guideline-Based Recommendations
Diagnosis
Use transthoracic echocardiogram (TTE) to grade MR and TR severity. Management
Monitor progression of regurgitation severity in patients with AF. Monitoring & Follow-up
Follow-up with serial echocardiograms at least 180 days apart. Risks
Patients with AF have a higher likelihood of clinically relevant TR progression. Patient & Prescribing Data
Patients aged 65 and older with documented AF or sinus rhythm.
Consider the impact of AF on the progression of tricuspid regurgitation.
Clinical Best Practices
Regular echocardiographic follow-up for patients with atrial fibrillation. Assess both mitral and tricuspid regurgitation severity in patients with AF. Related Resources & Content
