Differential associations of novel metaflammation indices with incident stroke across traditional Chinese medicine constitutions: a retrospective community-based cohort study of older adults - Scorecard - MDSpire

Differential associations of novel metaflammation indices with incident stroke across traditional Chinese medicine constitutions: a retrospective community-based cohort study of older adults

  • By

  • Yang Li

  • Jun Ni

  • You Li

  • Suyan Zhao

  • Yun Chen

  • June 3, 2026

  • 0 min

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Clinical Scorecard: Associations of New Metaflammation Indices with First Stroke Risk in Older Adults: A Retrospective Community-Based Study Across Traditional Chinese Medicine Constitutions

At a Glance

CategoryDetail
ConditionFirst Stroke Risk
Key MechanismsMetaflammation indices (LHR, MHR, NHR, PHR) associated with stroke risk.
Target PopulationCommunity-dwelling older adults (≥65 years).
Care SettingCommunity health service center.

Key Highlights

  • 36 incident stroke cases recorded during a 4-year follow-up.
  • LHR and PHR significantly associated with stroke risk after multivariable adjustment.
  • High-risk biased constitutions showed a significantly elevated stroke risk.
  • Associations of LHR and PHR varied across TCM constitution types.
  • No significant interaction observed among different constitution types.

Guideline-Based Recommendations

Diagnosis

  • Utilize metaflammation indices for stroke risk assessment.

Management

  • Integrate traditional risk factors with metaflammation indices.

Monitoring & Follow-up

  • Follow-up on stroke risk in older adults using identified indices.

Risks

  • Consider TCM constitution types when assessing stroke risk.

Patient & Prescribing Data

Older adults (≥65 years) without prior stroke.

Focus on personalized stroke risk assessment strategies.

Clinical Best Practices

  • Incorporate TCM constitution identification in stroke risk evaluation.
  • Monitor metaflammation indices in older adults for early intervention.

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