Assessing the Prognostic Significance of Interleukin-6, Neuropilin-1, and Amphiregulin Levels for Mortality Prediction in ICU Patients with Sepsis or Septic Shock - Scorecard - MDSpire

Assessing the Prognostic Significance of Interleukin-6, Neuropilin-1, and Amphiregulin Levels for Mortality Prediction in ICU Patients with Sepsis or Septic Shock

  • By

  • Fatma Karakoc Ozudogru

  • Banu Karaca

  • Huriye Erbak Yilmaz

  • Oguz Karalar

  • Murat Aksun

  • Kamil Gonderen

  • March 13, 2026

  • 0 min

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Clinical Scorecard: Assessing the Prognostic Significance of Interleukin-6, Neuropilin-1, and Amphiregulin Levels for Mortality Prediction in ICU Patients with Sepsis or Septic Shock

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target PopulationPatients aged ≥ 18 years admitted to ICU with Sepsis-3 criteria for sepsis or septic shock.
Care Setting

Key Highlights

  • IL-6 levels correlate with poor prognosis and mortality in severe sepsis and septic shock.
  • Nrp-1 may provide adjunct prognostic information beyond established clinical risk scores.
  • AREG contributes to tissue defense and repair mechanisms during inflammation.
  • This study evaluates the association of IL-6, Nrp-1, and AREG levels with 28- and 90-day mortality.

Guideline-Based Recommendations

Diagnosis

    Management

      Monitoring & Follow-up

      • Monitor IL-6, Nrp-1, and AREG levels for prognosis in ICU patients within the first 24 hours.

      Risks

        Patient & Prescribing Data

        Biomarkers may guide treatment decisions and prognostic evaluations, particularly in risk stratification.

        Clinical Best Practices

        • Collect blood samples for biomarker analysis within 24 hours of ICU admission to ensure timely and accurate results.
        • Use a multi-biomarker approach for better prognostic accuracy.

        References

        Original Source(s)

        Assessing the Prognostic Significance of Interleukin-6, Neuropilin-1, and Amphiregulin Levels for Mortality Prediction in ICU Patients with Sepsis or Septic Shock

        • by Fatma Karakoc Ozudogru, Banu Karaca, Huriye Erbak Yilmaz, Oguz Karalar, Murat Aksun, Kamil Gonderen

        • March 13, 2026

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