The onco-functional reorganization of language network underlying metaplasticity induced by gliomas
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By
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Lu Jin
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Zentao Zuo
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Jie Kang
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Fangzheng Liu
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Yifan Song
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Xin Liu
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Kefan Cai
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Wentao Wu
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Chuzhong Li
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Yazhuo Zhang
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Songbai Gui
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May 29, 2026
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Clinical Scorecard: Reorganization of Language Networks Associated with Metaplasticity in the Context of Gliomas
At a Glance
| Category | Detail |
|---|
| Condition | |
| Key Mechanisms | Dynamic reorganization of language networks influenced by tumor location and grade. |
| Target Population | |
| Care Setting | |
Key Highlights
- Activation patterns show right-hemispheric lateralization in domain-general networks.
- Task demands increase effective connections in reorganized language networks.
- Alterations in language network topology correlate with cognitive engagement.
Guideline-Based Recommendations
Diagnosis
- Utilize resting-state and task-based fMRI to assess language network reorganization.
Management
- Consider clinicopathological factors in surgical planning.
Monitoring & Follow-up
- Monitor language performance and network topology changes preoperatively.
Risks
- Be aware of variability in preoperative manifestations and postoperative recovery.
Patient & Prescribing Data
100 patients with gliomas and 127 matched normal controls.
Dynamic reorganization patterns may inform individualized treatment approaches.
Clinical Best Practices
- Incorporate neuroimaging findings into surgical decision-making.
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