Type-1 inflammatory imprinting and programmed responsiveness to CD40L enhance Siglec-1-dependent HIV-1 trans-infection by dendritic cells - Scorecard - MDSpire

Type-1 inflammatory imprinting and programmed responsiveness to CD40L enhance Siglec-1-dependent HIV-1 trans-infection by dendritic cells

  • By

  • E. Grace Bothwell

  • Allison E. DePuyt

  • Colleen R. Zaccard

  • Renee. R. Anderko

  • Peter E. J. Shoucair

  • Holly A. Bilben

  • Tatiana M. Garcia-Bates

  • Abigail D. Gerberick

  • Simon C. Watkins

  • Nicolas Sluis-Cremer

  • Charles R. Rinaldo

  • Robbie B. Mailliard

  • June 4, 2026

  • 0 min

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Clinical Scorecard: Inflammatory Type-1 Imprinting and CD40L-Mediated Programmed Responses Enhance Siglec-1-Dependent HIV-1 Trans-Infection in Dendritic Cells

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target PopulationIndividuals with HIV-1 infection, including specific age or demographic factors.
Care Setting

Key Highlights

  • highlight_2

Guideline-Based Recommendations

Diagnosis

    Management

    • Consider targeting CD40L signaling pathways to modulate dendritic cell function in HIV-1 infection, including specific interventions.

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        Include potential treatment options or clinical trials related to dendritic cell modulation.

        Clinical Best Practices

        • best_practice_2

        Related Resources & Content

        Original Source(s)

        Type-1 inflammatory imprinting and programmed responsiveness to CD40L enhance Siglec-1-dependent HIV-1 trans-infection by dendritic cells

        • by E. Grace Bothwell, Allison E. DePuyt, Colleen R. Zaccard, Renee. R. Anderko, Peter E. J. Shoucair, Holly A. Bilben, Tatiana M. Garcia-Bates, Abigail D. Gerberick, Simon C. Watkins, Nicolas Sluis-Cremer, Charles R. Rinaldo, Robbie B. Mailliard

        • June 4, 2026

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