Loss of ST8Sia6 mediated α-2,8-linked di-sialylation enhances T cell-dependent antibody responses and promotes autoimmunity in aged mice - Scorecard - MDSpire

Loss of ST8Sia6 mediated α-2,8-linked di-sialylation enhances T cell-dependent antibody responses and promotes autoimmunity in aged mice

  • By

  • Ronja Brüchert

  • Michael Hinzpeter-Schmidt

  • Bettina Röder

  • Mareike Krause

  • Stefanie Brey

  • Thomas H. Winkler

  • Falk F. R. Buettner

  • Martina Mühlenhoff

  • Lars Nitschke

  • July 2, 2026

  • 0 min

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Clinical Scorecard: Decreased ST8Sia6 Activity Leading to Increased α-2,8-linked Di-sialylation Enhances T Cell-Dependent Antibody Production and Fosters Autoimmunity in Aged Murine Models

At a Glance

CategoryDetail
ConditionAutoimmunity
Key MechanismsLoss of ST8Sia6-mediated α-2,8-linked di-sialylation enhances T cell-dependent immune responses.
Target PopulationAged murine models
Care SettingExperimental immunology research

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          Original Source(s)

          Loss of ST8Sia6 mediated α-2,8-linked di-sialylation enhances T cell-dependent antibody responses and promotes autoimmunity in aged mice

          • by Ronja Brüchert, Michael Hinzpeter-Schmidt, Bettina Röder, Mareike Krause, Stefanie Brey, Thomas H. Winkler, Falk F. R. Buettner, Martina Mühlenhoff, Lars Nitschke

          • July 2, 2026

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