Concurrent Patterns of Sleep Quality and Cognitive Performance Following Acute Ischemic Stroke: A Prospective Cohort Analysis Utilizing Group-Based Dual Trajectory Modeling
By
Li Wang
Yuhan Cheng
Sibei Wan
Qian Wu
Yan Shi
June 26, 2026
Clinical Scorecard: Concurrent Patterns of Sleep Quality and Cognitive Performance Following Acute Ischemic Stroke: A Prospective Cohort Analysis Utilizing Group-Based Dual Trajectory Modeling
At a Glance
Category Detail
Condition Acute Ischemic Stroke (AIS) Key Mechanisms Sleep quality and cognitive function interact through neuroinflammation, circadian rhythm disturbance, and brain network plasticity. Target Population AIS survivors Care Setting Single-center prospective cohort study
Key Highlights
Three distinct trajectory classes identified: sleep improvement-cognitive decline, sleep decline-cognitive improvement, and sleep improvement-cognitive improvement. Widowhood, left-hemisphere infarction, and prior stroke history associated with lower odds of sleep decline-cognitive improvement trajectory. Unmarried status linked to higher odds of sleep improvement-cognitive improvement trajectory. Guideline-Based Recommendations
Diagnosis
Assess sleep quality and cognitive function jointly in AIS patients. Management
Consider individualized management based on identified trajectory classes. Monitoring & Follow-up
Monitor changes in NIHSS, Barthel Index, IADL, and PHQ-9 across different trajectory classes. Risks
Recognize the risk of persistent poor sleep and cognitive decline in AIS survivors. Patient & Prescribing Data
515 AIS inpatients assessed at discharge and follow-up.
Joint trajectory modeling may inform targeted follow-up and interventions.
Clinical Best Practices
Utilize group-based dual trajectory modeling for assessing sleep and cognition post-stroke. Incorporate psychosocial factors in evaluating patient trajectories. Related Resources & Content
