Joint trajectories of sleep quality and cognitive function after acute ischemic stroke: a prospective cohort study using group-based dual trajectory modeling - Scorecard - MDSpire

Joint trajectories of sleep quality and cognitive function after acute ischemic stroke: a prospective cohort study using group-based dual trajectory modeling

  • By

  • Li Wang

  • Yuhan Cheng

  • Sibei Wan

  • Qian Wu

  • Yan Shi

  • June 26, 2026

  • 0 min

Share

Clinical Scorecard: Concurrent Patterns of Sleep Quality and Cognitive Performance Following Acute Ischemic Stroke: A Prospective Cohort Analysis Utilizing Group-Based Dual Trajectory Modeling

At a Glance

CategoryDetail
ConditionAcute Ischemic Stroke (AIS)
Key MechanismsSleep quality and cognitive function interact through neuroinflammation, circadian rhythm disturbance, and brain network plasticity.
Target PopulationAIS survivors
Care SettingSingle-center prospective cohort study

Key Highlights

  • Three distinct trajectory classes identified: sleep improvement-cognitive decline, sleep decline-cognitive improvement, and sleep improvement-cognitive improvement.
  • Widowhood, left-hemisphere infarction, and prior stroke history associated with lower odds of sleep decline-cognitive improvement trajectory.
  • Unmarried status linked to higher odds of sleep improvement-cognitive improvement trajectory.

Guideline-Based Recommendations

Diagnosis

  • Assess sleep quality and cognitive function jointly in AIS patients.

Management

  • Consider individualized management based on identified trajectory classes.

Monitoring & Follow-up

  • Monitor changes in NIHSS, Barthel Index, IADL, and PHQ-9 across different trajectory classes.

Risks

  • Recognize the risk of persistent poor sleep and cognitive decline in AIS survivors.

Patient & Prescribing Data

515 AIS inpatients assessed at discharge and follow-up.

Joint trajectory modeling may inform targeted follow-up and interventions.

Clinical Best Practices

  • Utilize group-based dual trajectory modeling for assessing sleep and cognition post-stroke.
  • Incorporate psychosocial factors in evaluating patient trajectories.

Related Resources & Content

Original Source(s)

Joint trajectories of sleep quality and cognitive function after acute ischemic stroke: a prospective cohort study using group-based dual trajectory modeling

  • by Li Wang, Yuhan Cheng, Sibei Wan, Qian Wu, Yan Shi

  • June 26, 2026

Related Content

Pediatric Bowhunter Syndrome: What Do We Know?

Bowhunter syndrome (BHS) is a rare but important cause of posterior circulation stroke in children, resulting from vertebral artery compression during head rotation.

  • June 19, 2026

  • 1 min
A review of the impact of circadian rhythm on motor function in stroke recovery patients

The effect of probiotic supplements on cognitive outcomes and neuroplasticity in elderly ischemic stroke survivors