Liver stiffness measured by transient elastography is associated with hepatic Fibrosis in children with portal vein thrombosis: a retrospective cross-sectional study - Scorecard - MDSpire

Liver stiffness measured by transient elastography is associated with hepatic Fibrosis in children with portal vein thrombosis: a retrospective cross-sectional study

  • By

  • Marwah Imad Shihab

  • Noor Mohammed Abdullah

  • Abdulnaser Karem Mhmeed

  • Enas Osama Hassan Omer

  • Aya Ahmed Shimal

  • Ahmed Osama Hassan Omer

  • Ahmed Dheyaa Al-Obaidi

  • June 5, 2026

  • 0 min

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Clinical Scorecard: Assessment of Liver Stiffness via Transient Elastography Correlates with Hepatic Fibrosis in Pediatric Patients with Portal Vein Thrombosis: A Retrospective Cross-Sectional Analysis

At a Glance

CategoryDetail
ConditionExtrahepatic portal vein obstruction (EHPVO) secondary to portal vein thrombosis (PVT)
Key MechanismsLiver stiffness measurement (LSM) via FibroScan (transient elastography) correlates with hepatic fibrosis stages.
Target PopulationChildren aged 3–18 years with EHPVO/PVT
Care SettingCairo University Children's Hospital

Key Highlights

  • 20 children included in the study, predominantly male (85%)
  • Hepatic fibrosis stages: 25% absent, 30% mild, 45% moderate
  • FibroScan (TE) showed good discriminative ability (AUROC 0.912)
  • Clinical features like bleeding history did not correlate with fibrosis stage
  • Platelet count and FibroScan (TE) are useful indicators of hepatic fibrosis

Guideline-Based Recommendations

Diagnosis

  • Doppler ultrasonography is the diagnostic modality of choice for portal hypertension.

Management

  • Endoscopic therapy is first-line treatment for acute variceal bleeding.

Monitoring & Follow-up

  • FibroScan (TE) can be used for evaluating and monitoring chronic liver diseases in children.

Risks

  • Liver biopsy complications include bleeding, pain, infection, and organ injury.

Patient & Prescribing Data

Children aged 3–18 years with EHPVO/PVT

Non-invasive imaging techniques like FibroScan (TE) are preferred to minimize invasive procedures.

Clinical Best Practices

  • Utilize FibroScan (TE) for non-invasive assessment of hepatic fibrosis in pediatric patients.
  • Consider endoscopic screening for gastroesophageal varices at diagnosis.

Related Resources & Content

Original Source(s)

Liver stiffness measured by transient elastography is associated with hepatic Fibrosis in children with portal vein thrombosis: a retrospective cross-sectional study

  • by Marwah Imad Shihab, Noor Mohammed Abdullah, Abdulnaser Karem Mhmeed, Enas Osama Hassan Omer, Aya Ahmed Shimal, Ahmed Osama Hassan Omer, Ahmed Dheyaa Al-Obaidi

  • June 5, 2026

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