Recurrent IDH-mutant astrocytoma WHO grade 4 diagnosed during pregnancy: case report with literature review
By
Muratbek A. Tleubergenov
Altynay Bakbayeva
Daniyar K. Zhamoldin
Aidos Doskaliyev
Ulday M. Urazova
Aigul D. Tolepbergenova
Aisa Z. Nurpeisov
Zhanat T. Takenov
Serik Akshulakov
May 28, 2026
Clinical Scorecard: IDH1-Mutant Astrocytoma WHO Grade 4 Diagnosed in a Pregnant Patient: A Case Study and Literature Review
At a Glance
Category Detail
Condition IDH1-mutant astrocytoma, WHO Grade 4 Key Mechanisms IDH mutations, CDKN2A/B deletions Target Population Pregnant women diagnosed with high-grade gliomas Care Setting Multidisciplinary care in specialized neurosurgery and obstetrics
Key Highlights
Rare case of IDH1-mutant astrocytoma diagnosed during pregnancy Aggressive tumor behavior with rapid recurrence post-surgery Importance of multidisciplinary coordination for management Need for clinical guidelines for high-grade glioma in pregnancy Prognostic implications of CDKN2A/B deletion in IDH-mutant tumors Guideline-Based Recommendations
Diagnosis
Utilize MRI findings to assess tumor characteristics and progression Management
Emergency neurosurgical intervention for symptomatic relief Simultaneous cesarean section and tumor resection if necessary Monitoring & Follow-up
Regular neurological assessments and imaging to monitor tumor progression Risks
Potential for accelerated tumor growth during pregnancy Patient & Prescribing Data
Pregnant women with high-grade gliomas
No standardized treatment guidelines currently exist
Clinical Best Practices
Timely neurosurgical intervention Integrated obstetric-neurosurgical strategies Multidisciplinary care approach Related Resources & Content
