Assessment of subventricular zone irradiation in glioblastoma patients - Scorecard - MDSpire

Assessment of subventricular zone irradiation in glioblastoma patients

  • By

  • Laya K. Pillai

  • Maitrik J. Mehta

  • Ankita Parikh

  • Niranjan Dash

  • Vinay Shivhare

  • Sonal Patel Shah

  • Akash Pandya

  • Jayesh Kumar Singh

  • Krishna Prajapati

  • Anjali Bahuguna

  • Raxit Darji

  • May 22, 2026

  • 0 min

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Clinical Scorecard: Evaluation of Irradiation Effects on the Subventricular Zone in Patients with Glioblastoma

At a Glance

CategoryDetail
Condition
Key MechanismsSubventricular zone (SVZ) involvement may contribute to tumor aggressiveness, recurrence, and therapeutic resistance.
Target Population
Care Setting

Key Highlights

  • Findings are exploratory and require larger prospective studies to validate.

Guideline-Based Recommendations

Diagnosis

    Management

    • Maximal safe surgical resection followed by temozolomide-based chemoradiation.
    • Prospective studies are needed to assess the impact of SVZ irradiation.

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        28 consecutive patients with GBM.

        Uniform treatment with IMRT/VMAT and temozolomide.

        Clinical Best Practices

        • Consider SVZ contact when assessing prognosis in GBM patients.
        • Evaluate the potential benefits and risks of incidental SVZ irradiation, including neurocognitive toxicity.

        Related Resources & Content

        Original Source(s)

        Assessment of subventricular zone irradiation in glioblastoma patients

        • by Laya K. Pillai, Maitrik J. Mehta, Ankita Parikh, Niranjan Dash, Vinay Shivhare, Sonal Patel Shah, Akash Pandya, Jayesh Kumar Singh, Krishna Prajapati, Anjali Bahuguna, Raxit Darji

        • May 22, 2026

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