NLRP3 inflammasome activation by particles and fibers: implications for human hazard assessment
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By
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Mathias Busch
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Gerrit Bredeck
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Hans Bouwmeester
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Roel P. F. Schins
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June 13, 2026
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Clinical Scorecard: Activation of the NLRP3 Inflammasome by Particulate Matter and Fibers: Relevance for Human Risk Evaluation
At a Glance
| Category | Detail |
|---|
| Condition | NLRP3 inflammasome activation leading to lung diseases |
| Key Mechanisms | Activation of NLRP3 inflammasome by particulate matter and fibers, resulting in IL-1β and IL-18 release |
| Target Population | Individuals exposed to occupational dusts and fibers |
| Care Setting | Occupational health and toxicology |
Key Highlights
Guideline-Based Recommendations
Diagnosis
Management
Monitoring & Follow-up
Risks
Patient & Prescribing Data
Workers in industries with exposure to crystalline silica, asbestos, and coal dust
Clinical Best Practices
Related Resources & Content
