Quercetagetin-rich flavonoids from marigold induce apoptosis inhibit metastasis of non-small cell lung cancer via the p53/p21 signaling pathway - Scorecard - MDSpire
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Quercetagetin-rich flavonoids from marigold induce apoptosis inhibit metastasis of non-small cell lung cancer via the p53/p21 signaling pathway
Clinical Scorecard: Flavonoids abundant in quercetagetin from marigold promote apoptosis and suppress metastasis in non-small cell lung cancer through the p53/p21 signaling pathway
At a Glance
Category
Detail
Condition
Non-small cell lung cancer (NSCLC)
Key Mechanisms
Induction of apoptosis and inhibition of proliferation/metastasis via the p53/p21 signaling pathway
Target Population
Patients with non-small cell lung cancer
Care Setting
Oncology research and treatment
Key Highlights
QG-MF significantly suppressed proliferation, migration, and invasion of NSCLC cells.
Induced apoptosis and cell cycle arrest in A549 and H661 cell lines.
In vivo studies showed marked inhibition of tumor growth in xenograft models.
Mechanistic studies revealed upregulation of p53, p21, Bax, and caspase-3, and downregulation of Bcl-2.
QG-MF was derived from marigold inflorescence residues, offering a sustainable source.
Guideline-Based Recommendations
Diagnosis
Diagnosis of NSCLC should consider histological examination and imaging studies.
Management
Consideration of natural compounds like QG-MF as adjunctive therapy in NSCLC.
Monitoring & Follow-up
Regular monitoring of tumor markers and imaging for treatment response.
Risks
Potential for drug resistance and side effects associated with conventional chemotherapy.
Patient & Prescribing Data
Patients diagnosed with non-small cell lung cancer.
QG-MF may provide a natural alternative with lower toxicity.
Clinical Best Practices
Incorporate natural products in the treatment regimen where applicable.
Monitor patient response to QG-MF in clinical settings.
