Potential neuroprotective and anticonvulsant effects of Ganoderma lucidum ethanol extract and its impact on affective comorbidities associated with pentylenetetrazol kindling model of epilepsy: behavioral, biochemical and histological studies - Scorecard - MDSpire

Potential neuroprotective and anticonvulsant effects of Ganoderma lucidum ethanol extract and its impact on affective comorbidities associated with pentylenetetrazol kindling model of epilepsy: behavioral, biochemical and histological studies

  • By

  • Itto Rahou Abdessamad

  • Bikjdaouene Leila

  • Bahbiti Youssef

  • Sqalli Houssaini Youssef

  • El Mekhlouf Youssef

  • Azeroil Fatima

  • Doumar Hanan

  • Dimaoui Amal

  • El-Hessni Aboubaker

  • Mesfioui Abdelhalem

  • July 10, 2026

  • 0 min

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Clinical Scorecard: Exploring the Neuroprotective and Anticonvulsant Properties of Ethanol Extract from Ganoderma lucidum and Its Effects on Affective Comorbidities in a Pentylenetetrazol Kindling Epilepsy Model: Behavioral, Biochemical, and Histological Investigations

At a Glance

CategoryDetail
ConditionEpilepsy
Key MechanismsOxidative stress and neuronal death
Target PopulationIndividuals with epilepsy
Care SettingPreclinical research

Key Highlights

  • Ganoderma lucidum extract (GLE) reduces seizure severity in a PTZ-induced epilepsy model.
  • GLE alleviates anxious and depressive behaviors in rats.
  • Biochemical analysis shows GLE reduces oxidative stress markers and restores antioxidant enzyme activities.
  • Histological studies indicate GLE reduces neurodegeneration in the prefrontal cortex.

Guideline-Based Recommendations

Diagnosis

  • Utilize the Racine five-point score for assessing seizure severity.

Management

  • Consider GLE as a potential adjunct treatment for epilepsy-related affective disorders.

Monitoring & Follow-up

  • Monitor oxidative stress markers and behavioral changes in epilepsy models.

Risks

  • Potential side effects of antiepileptic drugs warrant exploration of natural products like GLE.

Patient & Prescribing Data

Animal model (male Wistar rats)

GLE administered at 300 mg/kg shows neuroprotective and anticonvulsant effects.

Clinical Best Practices

  • Incorporate antioxidant strategies in managing epilepsy.
  • Evaluate the role of natural products in epilepsy treatment.

Related Resources & Content

Original Source(s)

Potential neuroprotective and anticonvulsant effects of Ganoderma lucidum ethanol extract and its impact on affective comorbidities associated with pentylenetetrazol kindling model of epilepsy: behavioral, biochemical and histological studies

  • by Itto Rahou Abdessamad, Bikjdaouene Leila, Bahbiti Youssef, Sqalli Houssaini Youssef, El Mekhlouf Youssef, Azeroil Fatima, Doumar Hanan, Dimaoui Amal, El-Hessni Aboubaker, Mesfioui Abdelhalem

  • July 10, 2026

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