Gut microbiota orchestrates bone homeostasis: a multi-pathway network from intestine to skeleton
By
Yanlong Gong
Xin Ma
Lele Wang
Pengwei Zhang
Tingting Liu
Yuanzhen Li
Wantao Dong
April 30, 2026
Clinical Scorecard: The Role of Gut Microbiota in Maintaining Bone Health: A Comprehensive Pathway Network Linking Intestine and Skeleton
At a Glance
Category Detail
Condition Osteoporosis (OP) Key Mechanisms Gut microbiota regulates bone homeostasis via the gut-bone axis, influencing osteoclast/osteoblast activity and systemic immunity. Target Population Individuals at risk of osteoporosis, particularly postmenopausal women. Care Setting Clinical settings focusing on metabolic bone diseases.
Key Highlights
Gut microbiota-derived metabolites modulate bone metabolism. Dysbiosis contributes to the progression of osteoporosis. Therapeutic interventions targeting gut microbiota show promise for OP management. Guideline-Based Recommendations
Diagnosis
Assess bone density and risk factors for osteoporosis. Management
Consider probiotics, prebiotics, and fecal microbiota transplantation as adjunct therapies. Monitoring & Follow-up
Regularly evaluate bone mineral density and gut microbiota composition. Risks
Monitor for potential adverse effects from microbiota-targeted therapies. Patient & Prescribing Data
Patients with osteoporosis, especially those with dysbiosis.
Integrating gut microbiota management may enhance treatment outcomes for osteoporosis.
Clinical Best Practices
Incorporate dietary modifications to support gut health. Educate patients on the role of gut microbiota in bone health. Collaborate with nutritionists for comprehensive management. References
