A Chlamydia trachomatis CPAF-STING agonist conjugate vaccine administered intramuscularly and intradermally is immunogenic in the pig model - Scorecard - MDSpire

A Chlamydia trachomatis CPAF-STING agonist conjugate vaccine administered intramuscularly and intradermally is immunogenic in the pig model

  • By

  • Leonie Bettin

  • Christine Unterweger

  • Maximiliane Dippel

  • Tamara Borysova

  • Maria Stadler

  • Jonathan Harris

  • James Rozzelle

  • Daisy Arroyo

  • Jeff Fairman

  • Taylor B. Poston

  • Eric Perouzel

  • Thierry Lioux

  • Juan F. Hernandez-Franco

  • Harm HogenEsch

  • Andrea Buzanich-Ladinig

  • Toni Darville

  • Tobias Käser

  • May 1, 2026

  • 0 min

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Clinical Scorecard: Immunogenicity of an Intramuscular and Intradermal Conjugate Vaccine Targeting Chlamydia trachomatis CPAF-STING Agonist in a Porcine Model

At a Glance

CategoryDetail
ConditionChlamydia trachomatis infection
Key MechanismsCPAF-STING agonist conjugate vaccine
Target PopulationPigs as a model for human chlamydia infections
Care SettingPreclinical research

Key Highlights

  • CPAF-STG1151 conjugate vaccine elicited the strongest T cell response.
  • Vaccine administration route (IM vs. ID) did not affect immune response intensity.
  • High anti-CPAF IgG serum concentrations observed with CPAF-STG1151.

Guideline-Based Recommendations

Diagnosis

  • Assess adaptive immune reactions using FluoroSpot assays and flow cytometry.

Management

  • Develop vaccines targeting CPAF with STING pathway activation.

Monitoring & Follow-up

  • Evaluate immune responses weekly post-vaccination.

Risks

  • Potential for severe complications from untreated Ct infections, such as PID.

Patient & Prescribing Data

Swine used as a model for human disease.

Innovative vaccine candidates show promise in eliciting immune responses.

Clinical Best Practices

  • Utilize pigs for preclinical vaccine development due to physiological similarities to humans.
  • Focus on inducing Th1-predominant immune responses for effective vaccine candidates.

References

Original Source(s)

A Chlamydia trachomatis CPAF-STING agonist conjugate vaccine administered intramuscularly and intradermally is immunogenic in the pig model

  • by Leonie Bettin, Christine Unterweger, Maximiliane Dippel, Tamara Borysova, Maria Stadler, Jonathan Harris, James Rozzelle, Daisy Arroyo, Jeff Fairman, Taylor B. Poston, Eric Perouzel, Thierry Lioux, Juan F. Hernandez-Franco, Harm HogenEsch, Andrea Buzanich-Ladinig, Toni Darville, Tobias Käser

  • May 1, 2026

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