Abnormal active myocardial relaxation by dipyridamole stress test in suspected early-stage heart failure with preserved ejection fraction: a retrospective exploratory analysis

E/e′ ratio significantly increased in suspected early-stage HFpEF patients during stress.
IVRT remained significantly higher in suspected early-stage HFpEF patients compared to HHD patients.
Myocardial performance index (MPI) did not improve during DipSE in suspected early-stage HFpEF patients.
Patients with ST-segment depression had worse MPI compared to those without during DipSE.
HFpEF represents up to 50% of heart failure cases, with increasing incidence.

Use NT-proBNP levels and echocardiographic criteria to diagnose HFpEF. [Source needed]

Tailor therapeutic strategies based on individual pathogenetic mechanisms. [Source needed]

Assess diastolic function and LV filling pressures during stress echocardiography. [Source needed]

Patients with significant ST-segment depression may have worse myocardial performance. [Source needed]

Patients with NT-proBNP ≥ 125 pg/mL are considered affected by HFpEF. [Source needed]

Conduct comprehensive echocardiographic assessments of diastolic and systolic LV function. [Source needed]
Utilize dipyridamole stress echocardiography to evaluate CMD and diastolic dysfunction. [Source needed]

Clinical Scorecard: Altered Myocardial Relaxation During Dipyridamole Stress Testing in Patients with Suspected Early-Stage Heart Failure and Preserved Ejection Fraction: A Retrospective Exploratory Study