CD38+ NK cells: novel players in immunoregulation
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By
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Xiaotian Chang
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Kehua Fang
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May 29, 2026
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Clinical Scorecard: CD38-Expressing NK Cells: Emerging Contributors to Immune Regulation
At a Glance
| Category | Detail |
|---|
| Condition | |
| Key Mechanisms | CD38+ NK cells exhibit opposing regulatory effects on immune responses. |
| Target Population | |
| Care Setting | |
Key Highlights
- Increased CD38+ NK cell proportions are found in rheumatoid arthritis and colorectal cancer patients.
- CD38+ NK cells can suppress Treg differentiation in rheumatoid arthritis.
- In colorectal cancer, CD38+ NK cells promote Treg differentiation and macrophage polarization.
Guideline-Based Recommendations
Diagnosis
- Monitor CD38+ NK cell proportions in patients with rheumatoid arthritis.
Management
Monitoring & Follow-up
- Assess changes in CD38+ NK cell populations in response to treatment.
Risks
Patient & Prescribing Data
Anti-CD38 antibodies may alter cytokine production.
Clinical Best Practices
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