Association of preoperative CT-derived visceral adipose tissue index with synchronous metastasis and metastasis-free survival after curative-intent surgery in colorectal cancer - Scorecard - MDSpire
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Association of preoperative CT-derived visceral adipose tissue index with synchronous metastasis and metastasis-free survival after curative-intent surgery in colorectal cancer
Clinical Scorecard: Relationship Between Preoperative CT-Based Visceral Adipose Tissue Index and Synchronous Metastasis as Well as Metastasis-Free Survival Following Curative Surgery in Colorectal Cancer
At a Glance
Category
Detail
Condition
Colorectal Cancer (CRC)
Key Mechanisms
Computed tomography-derived visceral adipose tissue index (VATI) associated with synchronous metastasis and metastasis-free survival.
Target Population
Patients with newly diagnosed colorectal cancer undergoing curative-intent surgery.
Care Setting
Retrospective two-center study.
Key Highlights
VATI independently associated with synchronous metastasis (OR, 1.110; p < 0.001).
High-VATI group had shorter metastasis-free survival (log-rank p = 0.001).
VATI remained independently associated with shorter MFS (HR, 1.017; p = 0.021).
Study included 468 patients (77 mCRC, 391 nmCRC).
No significant differences in body composition metrics between early and late metastasis groups.
Guideline-Based Recommendations
Diagnosis
Use CT-derived VATI for risk stratification in CRC patients.
Management
Consider VATI in postoperative surveillance strategies.
Monitoring & Follow-up
Monitor patients with high VATI for potential metastasis.
Risks
Higher VATI linked to increased risk of synchronous metastasis and shorter MFS.
Patient & Prescribing Data
Patients with newly diagnosed colorectal cancer (n = 468).
VATI can serve as a biomarker for identifying high-risk patients.
Clinical Best Practices
Incorporate VATI assessment in preoperative evaluations.
Utilize VATI for tailoring postoperative follow-up.
