Clinical Scorecard: Preoperative Depletion of Gut Microbiota and Metabolomic Profiles as Predictors of Postoperative Pneumonia in Patients Undergoing Surgery for Intracranial Lesions: A Multi-Omics Prospective Study

At a Glance

Key Highlights

• Significant preoperative depletion of Roseburia in POP patients
• Metabolic deficiency state identified in POP patients involving impaired fructose and mannose metabolism
• Preoperative Roseburia abundance correlated with anti-inflammatory metabolite 1-methylnicotinamide
• Top 10 preoperative metabolites predicted POP with an AUC of 1.0
• Integration of microbiota and metabolomics offers a novel pathway for early intervention

Guideline-Based Recommendations

Diagnosis

• Postoperative pulmonary infection diagnosed using Clinical Pulmonary Infection Score (CPIS)

Management

• Monitoring preoperative metabolic signatures for risk stratification

Monitoring & Follow-up

• Assessing gut microbiota and metabolic profiles preoperatively

Risks

• Increased susceptibility to postoperative pneumonia due to surgical trauma and impaired immune response

Patient & Prescribing Data

Adult patients with intracranial space-occupying lesions

Focus on gut microbiota and metabolic health preoperatively to mitigate infection risk

Clinical Best Practices

• Conduct comprehensive preoperative assessments of gut microbiota
• Utilize metabolomic profiling to identify high-risk patients
• Implement strategies to restore gut microbiota balance preoperatively

Related Resources & Content

• Clinical Pulmonary Infection Score (CPIS)