Preoperative gut microbiota depletion and metabolomic signatures predict postoperative pneumonia in patients with intracranial space-occupying lesions: a multi-omics prospective cohort study - Scorecard - MDSpire
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Preoperative Depletion of Gut Microbiota and Metabolomic Profiles as Predictors of Postoperative Pneumonia in Patients Undergoing Surgery for Intracranial Lesions: A Multi-Omics Prospective Study
Clinical Scorecard: Preoperative Depletion of Gut Microbiota and Metabolomic Profiles as Predictors of Postoperative Pneumonia in Patients Undergoing Surgery for Intracranial Lesions: A Multi-Omics Prospective Study
At a Glance
Category
Detail
Condition
Postoperative Pneumonia (POP)
Key Mechanisms
Preoperative gut microbiota depletion and metabolic deficiency
Target Population
Adult patients with intracranial space-occupying lesions undergoing surgery
Care Setting
Neurosurgery
Key Highlights
Significant preoperative depletion of Roseburia in POP patients
Metabolic deficiency state identified in POP patients involving impaired fructose and mannose metabolism
Preoperative Roseburia abundance correlated with anti-inflammatory metabolite 1-methylnicotinamide
Top 10 preoperative metabolites predicted POP with an AUC of 1.0
Integration of microbiota and metabolomics offers a novel pathway for early intervention
Guideline-Based Recommendations
Diagnosis
Postoperative pulmonary infection diagnosed using Clinical Pulmonary Infection Score (CPIS)
Management
Monitoring preoperative metabolic signatures for risk stratification
Monitoring & Follow-up
Assessing gut microbiota and metabolic profiles preoperatively
Risks
Increased susceptibility to postoperative pneumonia due to surgical trauma and impaired immune response
Patient & Prescribing Data
Adult patients with intracranial space-occupying lesions
Focus on gut microbiota and metabolic health preoperatively to mitigate infection risk
Clinical Best Practices
Conduct comprehensive preoperative assessments of gut microbiota
Utilize metabolomic profiling to identify high-risk patients
Implement strategies to restore gut microbiota balance preoperatively
