Cognitive Impairment Associated with Mild to Moderate Migraine Episodes: Possible Effects on Workplace Attendance
By
Yoji Yamaguchi
Masaaki Kohta
Kenji Ishikawa
Yasuo Naito
Michio Yamaguchi
Yusuke Ikeuchi
Hiroyasu Shose
Kazuhiro Tanaka
Atsushi Fujita
Takashi Sasayama
March 4, 2026
Clinical Scorecard: Cognitive Impairment Associated with Mild to Moderate Migraine Episodes: Possible Effects on Workplace Attendance
At a Glance
Category Detail
Condition Migraine Key Mechanisms Cognitive impairment during migraine attacks affects workplace productivity. Target Population Individuals aged 18–80 years diagnosed with migraine with or without aura. Care Setting Clinical assessment by headache specialists.
Key Highlights
Migraine affects approximately 11.6% of the global population. Cognitive function is impaired during mild to moderate migraine attacks. Economic losses due to migraine-related presenteeism can reach up to 3 billion USD annually. 80% of migraine patients experience associated symptoms impacting productivity. Cognitive assessments were conducted without acute pharmacological treatment influence. Guideline-Based Recommendations
Diagnosis
Diagnosis confirmed by clinical assessment following ICHD-3 guidelines. Management
Exclude patients with severe headaches from cognitive assessments. Monitoring & Follow-up
Evaluate cognitive function during mild to moderate headache attacks. Risks
Cognitive impairment may lead to reduced workplace productivity. Patient & Prescribing Data
Individuals with mild to moderate migraine attacks.
Cognitive function improves with appropriate pharmacological treatment post-attack.
Clinical Best Practices
Conduct cognitive assessments during headache attacks without acute medication influence. Utilize standardized neuropsychological tests for evaluation. Related Resources & Content
