Cognitive Impairment Associated with Mild to Moderate Migraine Episodes: Possible Effects on Workplace Attendance
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By
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Yoji Yamaguchi
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Masaaki Kohta
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Kenji Ishikawa
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Yasuo Naito
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Michio Yamaguchi
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Yusuke Ikeuchi
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Hiroyasu Shose
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Kazuhiro Tanaka
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Atsushi Fujita
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Takashi Sasayama
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March 4, 2026
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Clinical Scorecard: Cognitive Impairment Associated with Mild to Moderate Migraine Episodes: Possible Effects on Workplace Attendance
At a Glance
| Category | Detail |
|---|
| Condition | Migraine |
| Key Mechanisms | Cognitive impairment during migraine attacks affects workplace productivity. |
| Target Population | Individuals aged 18–80 years diagnosed with migraine with or without aura. |
| Care Setting | Clinical assessment by headache specialists. |
Key Highlights
- Migraine affects approximately 11.6% of the global population.
- Cognitive function is impaired during mild to moderate migraine attacks.
- Economic losses due to migraine-related presenteeism can reach up to 3 billion USD annually.
- 80% of migraine patients experience associated symptoms impacting productivity.
- Cognitive assessments were conducted without acute pharmacological treatment influence.
Guideline-Based Recommendations
Diagnosis
- Diagnosis confirmed by clinical assessment following ICHD-3 guidelines.
Management
- Exclude patients with severe headaches from cognitive assessments.
Monitoring & Follow-up
- Evaluate cognitive function during mild to moderate headache attacks.
Risks
- Cognitive impairment may lead to reduced workplace productivity.
Patient & Prescribing Data
Individuals with mild to moderate migraine attacks.
Cognitive function improves with appropriate pharmacological treatment post-attack.
Clinical Best Practices
- Conduct cognitive assessments during headache attacks without acute medication influence.
- Utilize standardized neuropsychological tests for evaluation.
References
