Infusion-related reactions and premedication patterns in ublituximab-treated multiple sclerosis patients: a multicenter real-world study - Scorecard - MDSpire
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Infusion-related reactions and premedication patterns in ublituximab-treated multiple sclerosis patients: a multicenter real-world study
Clinical Scorecard: Characterization of Infusion-Related Reactions and Premedication Practices in Multiple Sclerosis Patients Treated with Ublituximab: A Multicenter Real-World Analysis
At a Glance
Category
Detail
Condition
Multiple Sclerosis
Key Mechanisms
Ublituximab is a glycoengineered anti-CD20 monoclonal antibody that reduces MS relapses and is associated with infusion-related reactions (IRRs).
Target Population
Patients with multiple sclerosis (MS) treated with ublituximab.
Care Setting
Multicenter real-world clinical practice.
Key Highlights
34.8% of patients experienced mild to moderate IRRs.
All patients received premedication prior to ublituximab infusion.
Acetaminophen dosage was significantly associated with IRR occurrence.
IRRs were more common at the first infusion, with a decline in subsequent infusions.
No independent predictors of IRRs were identified.
Guideline-Based Recommendations
Diagnosis
Patients diagnosed with any subtype of multiple sclerosis.
Management
Ublituximab infusions should be administered with premedication to mitigate IRRs.
Monitoring & Follow-up
Monitor for IRRs during and after ublituximab infusion.
Risks
Risk of infusion-related reactions, particularly during the first infusion.
Patient & Prescribing Data
Patients with multiple sclerosis receiving ublituximab.
Premedication practices vary across centers; acetaminophen is a key component associated with IRR occurrence.
Clinical Best Practices
Administer premedication including antihistamines and corticosteroids before ublituximab infusion.
Monitor patients closely for IRRs, especially during the first infusion.
by Anas Z. Nourelden, Parker R. Scott, Sam I. Hooshmand, Izabela Mazur, Felicia Mada, Tesiley Ash, Nidhi Patel, Jacob Rube, Kalyan Yarraguntla, Carey Deluca, Patti Yager-Stone, Ryan Havens, Mitchell Wallin, Anza B. Memon
