Investigation of Epicardial Adipose Tissue and Its Correlation with Hypertension Through Radiomic Analysis in Photon-Counting CT
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By
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Felix Waßmer
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Jannik Barz
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Dominik Nörenberg
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Stefan O. Schoenberg
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Alexander Hertel
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Isabelle Ayx
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July 15, 2026
Clinical Scorecard: Investigation of Epicardial Adipose Tissue and Its Correlation with Hypertension Through Radiomic Analysis in Photon-Counting CT
At a Glance
| Category | Detail |
|---|
| Condition | Epicardial Adipose Tissue and Hypertension |
| Key Mechanisms | Radiomic analysis of epicardial adipose tissue using photon-counting CT to assess cardiovascular risk factors. |
| Target Population | Patients without coronary artery disease, aged 18 to 80 years. |
| Care Setting | Single-center retrospective study in a clinical imaging context. |
Key Highlights
- 114 patients without coronary artery disease were analyzed.
- Lower mean epicardial adipose tissue attenuation was observed in the hypertension group.
- Logistic regression model achieved a cross-validated AUC of 0.65.
- Radiomics analysis provides objective quantification of cardiac structures.
- Integration of radiomics into cardiac CT is in early stages but shows potential.
Guideline-Based Recommendations
Diagnosis
- Use of cardiac CT for assessment of epicardial adipose tissue.
Management
- Consideration of radiomic features in cardiovascular risk stratification.
Monitoring & Follow-up
- Further validation of radiomic findings in larger cohorts.
Risks
- Challenges related to feature reproducibility and standardization.
Patient & Prescribing Data
Patients with no evidence of coronary artery calcification or stenosis.
Exploratory findings suggest potential for individualized risk assessment.
Clinical Best Practices
- Utilize advanced imaging techniques for accurate assessment of epicardial adipose tissue.
- Incorporate radiomics into routine cardiac imaging for enhanced risk stratification.
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